Results 81 to 90 of about 137,726 (297)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Effective algorithms for integrated scheduling of handling equipment at automated container terminals [PDF]

In this paper we consider the problem of integrated scheduling of various types of handling equipment at an automated container terminal, where the objective is to minimize the makespan of the schedule.
Meersmans, P.J.M., Wagelmans, A.P.M.
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Storage Management of Hazardous Containers Using the Genetic Algorithm

Transport and Telecommunication, 2016
This work discusses the problem of dangerous containers storage in a container terminal. Container terminal represents an essential intermodal interfaces for global transportation network.
Yachba Khadidja, Gelareh Shahin, Bouamrane Karim   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The impact of container call size - evidence from simulation modelling

Maritime Transport Research
We present an analysis of the impact of large container ship call sizes on the operational efficiency of container terminals as well as on hinterland modes of transport.
Albert Veenstra, Arjen de Waal
doaj   +1 more source

Developing a decarbonization policy model of container terminal clusters [PDF]

Journal of International Logistics and Trade
Purpose – The purpose of this research is to develop a set of policies to solve the decarbonization issues of container terminal clusters. Design/methodology/approach – This research used the system dynamics approach to develop an integrated multi-issue ...
Armand Omar Moeis, Chatarina Petra Salim, Andri Dwi Setiawan, Arry Rahmawan Destyanto   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

A multi-criteria evaluation of container terminal technologies applying the COPRAS-G method

Transport, 2012
Over the recent years, the usage of containers has dramatically increased; subsequently, port container terminals annually serve more and more intensive flows, which leads to the necessity to find the ways of increasing terminal performance in order to ...
Jurgita Barysienė
doaj   +1 more source