Results 91 to 100 of about 45,740 (299)

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

The Post-War Port Industry Development Models: the Effects on the Economic Development of the Port’s Hinterland. [PDF]

open access: yes
The economic development of the port industry that followed the Second World War was based upon two economic theories trends. Until the late 70’s the model based on Keynesianism forms the basic idea for ownership, infrastructure, investment, pricing ...
Angeliki Pardali   +1 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

A method integrating simulation and reinforcement learning for operation scheduling in container terminals

open access: yesTransport, 2012
The objective of operation scheduling in container terminals is to determine a schedule that minimizes time for loading or unloading a given set of containers.
Qingcheng Zeng   +2 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A decision support tool for container terminal optimization within the berth subsystem

open access: yesTransport, 2016
The article deals with a current problem faced by all ports: how to enable container terminals to keep up with the development of container ships, which, due to economies of scale, are constantly increasing in size.
Maja Stojaković, Elen Twrdy
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transshipment container terminals

open access: yes, 2020
The ever increasing number of containers to be transported necessitates expanding thecapacity of container terminals. This can be achieved either by enlarging the containerterminals physically or by managing the container terminals better. Since the first alternative is costly, and sometimes not possible due to limited land, container terminal managers
openaire   +1 more source

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