Results 51 to 60 of about 64,555 (258)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Combined global and local semantic feature–based image retrieval analysis with interactive feedback

open access: yesMeasurement + Control, 2020
Nowadays, user expects image retrieval systems using a large database as an active research area for the investigators. Generally, content-based image retrieval system retrieves the images based on the low-level features, high-level features, or the ...
A Anandh, K Mala, R Suresh Babu
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Metadata for Content-Based Image Retrieval

open access: yesStudia Universitatis Babes-Bolyai: Series Informatica, 2010
This paper presents an image retrieval technique that combines content based image retrieval with pre-computed metadata-based image retrieval. The resulting system will have the advantages of both approaches: the speed/efficiency of metadata-based image ...
Adrian Sterca, Daniela Miron
doaj  

Content‐based retinal image retrieval

open access: yesIET Image Processing, 2019
The study presents a content‐based retrieval technique for retinal images. Given a query image, the aim is to automatically retrieve the relevant disease images (i.e. diabetic retinopathy, coats and choroidal neovascularisation) from the database. The proposed technique applies different pre‐processing steps to enhance the region of the exudate present
Komal Nain Sukhia   +2 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Co-word mapping of Image Retrieval based on Web of Science-Indexed Papers [PDF]

open access: yesمجله علم‌سنجی کاسپین, 2017
Background and aim: Given the special status and wide usage of image retrieval in various fields, the present investigation studied on the research trends and significant factors within the field of image retrieval and drawing the co-word map based on ...
Samira Daniali   +2 more
doaj  

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Introducing Multimedia Information Retrieval to libraries

open access: yesJLIS.it, 2016
The paper aims to introduce libraries to the view that operating within the terms of traditional Information Retrieval (IR), only through textual language, is limitative, and that considering broader criteria, as those of Multimedia Information ...
Roberto Raieli
doaj   +6 more sources

Content based image retrieval through object features

open access: yesJournal of Computer Science and Technology, 2018
Digital images are an increasingly important class of data, especially as computers become more usable with greater memory and communication capacities. As the demand for digital images increases, the need to store and retrieve images in an intuitive and
Ramanujam Meenakshi
doaj  

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