Results 81 to 90 of about 4,501 (286)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Performance of Queueing Models for MISO Content-Centric Networks. [PDF]

, 2021
Ramkumar Raghu, Mahadesh Panju, Vinod Sharma   +2 more
openalex  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A chunk caching location and searching scheme in Content Centric Networking [PDF]

, 2012
Yang Li, T. Lin, Hui Tang, Peng Sun
openalex   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

A Cache Management Scheme for Efficient Content Eviction and Replication in Cache Networks

IEEE Access, 2017
To cope with the ongoing changing demands of the internet, `in-network caching' has been presented as an application solution for two decades. With the advent of information-centric network (ICN) architecture, `in-network caching' becomes a network level
Muhammad Bilal, Shin-Gak Kang
doaj   +1 more source

Content-Centric Networking - Architectural Overview and Protocol Description [PDF]

, 2017
Marc Mosko, Ignacio Solís, Christopher A. Wood   +2 more
openalex   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Evaluating CRoS-NDN: a comparative performance analysis of a controller-based routing scheme for named-data networking

Journal of Internet Services and Applications, 2019
The huge amount of content names available in Named-Data Networking (NDN) challenges both the required routing table size and the techniques for locating and forwarding information. Content copies and content mobility exacerbate the scalability challenge
João Vitor Torres, Igor Drummond Alvarenga, Raouf Boutaba, Otto Carlos Muniz Bandeira Duarte   +3 more
doaj   +1 more source

Privacy-Aware Multipath Video Caching for Content-Centric Networks [PDF]

, 2016
Qinghua Wu, Zhenyu Li, Gareth Tyson, Steve Uhlig, Mohamed Ali Kâafar, Gaogang Xie   +5 more
openalex   +1 more source