Results 121 to 130 of about 23,717,506 (363)

Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker.

open access: yesJournal of Investigative Dermatology, 1982
We examined the hypothesis that myeloperoxidase (MPO), a plentiful constituent of neutrophils, might serve as a marker for tissue neutrophil content. To completely extract MPO from either neutrophils or skin, hexadecyltrimethylammonium bromide (HTAB) was
P. Bradley   +3 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

Open Content Alliance Update [PDF]

open access: yes, 2008
As part of the Boston Library Consortium, in the fall of 2007 the University of New Hampshire Library began participating in the Open Content Alliance (OCA), a mass digitization project intended to make scanned library materials freely accessible to the ...
Exline, Eleta
core   +1 more source

Content-based ontology ranking [PDF]

open access: yes, 2006
Techniques to rank ontologies are crucial to aid and encourage the re-use of publicly available ontologies. This paper presents a system that obtains a list of ontologies from a search engine that contain the terms provided by a knowledge engineer and ...
Alani, Harith, Jones, Matthew
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Reliability in Content Analysis: Some Common Misconceptions and Recommendations

open access: yes, 2004
In a recent article in this journal, Lombard, Snyder-Duch, and Bracken (2002) surveyed 200 content analyses for their reporting of reliability tests, compared the virtues and drawbacks of five popular reliability measures, and proposed guidelines and ...
K. Krippendorff
semanticscholar   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

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