Results 271 to 280 of about 20,521,756 (287)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Research progress on the effects of traditional Chinese medicine processing on the structure, content and biological activity of polysaccharides in traditional Chinese medicines. [PDF]

Front Chem
Guan J, Zhang J, Tian X, Xue J, Gao R, Hou A, Kuang H, Yang L, Jiang H.   +8 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

The quality and reliability of short videos about migraine on Chinese social Media platforms (BiliBili and TikTok): A cross-sectional study. [PDF]

Digit Health
Qian S, Gu J, Zhao H.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Optimization of Sweet Leaf (<i>Sauropus androgynus</i> L. Merr)-Amaranth (<i>Amaranthus hybridus</i> L.) Vegetable Leather With Carrageenan and Sorbitol. [PDF]

Scientifica (Cairo)
Purwoto H, Purnamasari AP, Rusbana TB, Nurtiana W, Putri RPG, Soraya M, Laksono H.   +6 more
europepmc   +1 more source

The influence of lime type on the properties of traditional lime-soil materials. [PDF]

PLoS One
Fang S, Hu W, Chen X, Xie L, Cai L.
europepmc   +1 more source

Functional Trait Space Reveals Resource Use Strategies of Woody Plants in the Lijiang River Basin. [PDF]

Ecol Evol
Duan BJ, Wei SG, Li L, Bai KD, Li XJ, Yin YH, Wang X, Hu Y.   +7 more
europepmc   +1 more source