Results 281 to 290 of about 4,466,597 (305)

Roadmap and Reflections on Expanding Equity, Diversity, Inclusion, Indigeneity, and Accessibility in Pharmacology Curricula. [PDF]

Pharmacol Res Perspect
Kaur G, Rajakumar RCJ, Agabani Z, Arnot M.   +3 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Optimizing sintering air volume for enhanced lean gas recovery and environmental performance. [PDF]

Sci Rep
Guo X, Ji J, Gao Y, Wu X, Guo Y, Wang W, Wen M, Wu X, Zhang Z.   +8 more
europepmc   +1 more source

MIF as an oncogenic driver of low‐heterogeneity melanomas

Molecular Oncology, EarlyView.
Shvefel and colleagues identified tumor‐secreted macrophage migration inhibitory factor (MIF) as an upregulated cytokine that mediates immune resistance in melanomas with low‐intratumoral heterogeneity. MIF and its functional paralogue D‐dopachrome tautomerase (D‐DT or MIF‐2) have overlapping but nonidentical signaling functions and are hypothesized to
Thuy T. Tran, Gabriela Athziri Sánchez‐Zuno, Rajan P. Kulkarni, Harriet M. Kluger, Richard Bucala   +4 more
wiley   +1 more source

A Thermo-TDR Sensor for Simultaneous Measurement of Unfrozen Water Content and Thermal Conductivity of Frozen Soil. [PDF]

Sensors (Basel)
Liu P, Fan S, Mu Q, Zhang Q, Tang L, Liu J, Cui F, Liu Z, Wang X.   +8 more
europepmc   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Diet and Psoriasis-Related Information on Instagram: A Quality and Content Analysis of Posts Under Popular Psoriasis Hashtags. [PDF]

J Hum Nutr Diet
Cowan S, Hawkins P, Marks G, Fallaize R.
europepmc   +1 more source

Quality of English- and Spanish-language online content about prostate cancer genetics: Insights into potential contributors to prostate cancer disparities. [PDF]

BJUI Compass
Abusamra SM, Cholán VO, Giri VN, Vadaparampil ST, Pérez-Rosas V, Rivera A, Nolasco TS, Camacho MR, Byrne N, Loeb S.   +9 more
europepmc   +1 more source

Generative artificial intelligence and machine learning methods to screen social media content. [PDF]

PeerJ Comput Sci
Sharp K, Ouellette RR, Singh RSR, DeVito EE, Kamdar N, de la Noval A, Murthy D, Kong G.   +7 more
europepmc   +1 more source