Results 71 to 80 of about 687,174 (294)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
ANALYSIS OF CONTENT RECOMMENDATION METHODS IN INFORMATION SERVICES
Informatyka, Automatyka, Pomiary w Gospodarce i Ochronie ŚrodowiskaThe object of the research is the process of selecting a content recommendation method in information services. The study's relevance stems from the rapid development of informational and entertainment resources and the increasing volume of data they ...
Oleksandr Necheporuk +4 more
doaj +1 more source
Deep Belief Nets for Topic Modeling [PDF]
, 2015 Applying traditional collaborative filtering to digital publishing is challenging because user data is very sparse due to the high volume of documents relative to the number of users.
Arngren, Morten +2 more
core +1 more source
StarSpace: Embed All The Things!
, 2017 We present StarSpace, a general-purpose neural embedding model that can solve a wide variety of problems: labeling tasks such as text classification, ranking tasks such as information retrieval/web search, collaborative filtering-based or content-based ...
Adams, Keith +5 more
core +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A Recommendation System Based on Fuzzy Signature
IEEE AccessIn recent years, recommendation systems have become essential tools for managing the overwhelming volume of information users face daily. In the context of Technology Enhanced Learning (TEL), for instance, where learners can be faced with a large variety
Giuseppe D'Aniello +2 more
doaj +1 more source
, 2010 Recommender Systems apply machine learning and data mining techniques for filtering unseen information and can predict whether a user would like a given resource.
Ghazanfar, Mustansar +1 more
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