Results 61 to 70 of about 3,514 (254)

RBFNN: a radial basis function neural network model for detecting and mitigating the cache pollution attacks in named data networking

IET Networks, 2020
Named data networking (NDN) corresponds to content‐centric networking, content‐based networking, and data‐oriented networking. Future internet architecture is modelled to overcome the fundamental limitations of the present internet protocol‐based ...
Ramachandira Moorthy Buvanesvari, Kanagaraj Suresh Joseph   +1 more
doaj   +1 more source

Content-Centric Mobile Edge Caching

IEEE Access, 2020
With the explosion of data volume, it becomes challenging to deliver high quality service to mobile users. Therefore, edge caching has received significant attentions since it can bring contents near mobile users, to boost spectral efficiency, and reduce
Tiankui Zhang, Xinyuan Fang, Yuanwei Liu, Arumugam Nallanathan   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

TVDR: A Two-Level Virtual Domain Routing Scheme for Content-Centric Networking

IEEE Access, 2018
In content-centric networking (CCN), the content is retrieved based on its name with the aid of in-network caching, instead of relying on IP address. Since the number of content names is several orders of magnitude higher than that of IP addresses, it ...
Jie Li, Xingwei Wang, Min Huang
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Formalization of the Behavior of Content-Centric Networking

Procedia Computer Science, 2015
AbstractContent-Centric Networking (CCN) is a communications architecture that is based on the names of contents, rather than on ad- dresses. The protocol used in CCN does not apply to end-to-end communications but is, instead, for network-wide communications. Each node sends packets to the nodes that are connected to it, which communicate with further
Sosuke Moriguchi, Takashi Morishima, Mizuki Goto, Kazuko Takahashi 0001   +3 more
openaire   +1 more source