Results 71 to 80 of about 3,350 (255)
A Software-Defined Information-Centric Network Architecture
Guangtongxin yanjiu, 2016 Existing proposals of Software-Defined Information-Centric Networking（SDICN）are difficult to support massive content delivery and to enable respective updates of switching and buffering components.This motivates us to propose an overlay-based SDICN ...
LI Keng, CHEN Jing-wen, JIANG Yu, MA Lin
doaj
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
A Cache Management Scheme for Efficient Content Eviction and Replication in Cache Networks
IEEE Access, 2017 To cope with the ongoing changing demands of the internet, `in-network caching' has been presented as an application solution for two decades. With the advent of information-centric network (ICN) architecture, `in-network caching' becomes a network level
Muhammad Bilal, Shin-Gak Kang
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Journal of Internet Services and Applications, 2019 The huge amount of content names available in Named-Data Networking (NDN) challenges both the required routing table size and the techniques for locating and forwarding information. Content copies and content mobility exacerbate the scalability challenge
João Vitor Torres +3 more
doaj +1 more source
Formalization of the Behavior of Content-Centric Networking
Procedia Computer Science, 2015 AbstractContent-Centric Networking (CCN) is a communications architecture that is based on the names of contents, rather than on ad- dresses. The protocol used in CCN does not apply to end-to-end communications but is, instead, for network-wide communications. Each node sends packets to the nodes that are connected to it, which communicate with further
Sosuke Moriguchi +3 more
openaire +1 more source