Results 121 to 130 of about 6,117,480 (275)

The integration of 21st century skills in the curriculum of education

Heliyon
The premise of this study, utilizing content analysis and descriptive qualitative designs, posited that teachers' comprehension of 21st-century/4Cs skills' could define the caliber of educational materials in higher education institutions.
Herlinawati Herlinawati, Marwa Marwa, Noriah Ismail, Junaidi, Ledya Oktavia Liza, Dominikus David Biondi Situmorang   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Role of ideology and the media in promoting familiarity and trust in political decisions: the case of Argentina's 2019 elections

Frontiers in Social Psychology
IntroductionToday's democratic systems are at a crossroads in the face of the rising “new right wing”, a reactive form of political polarization. Although much research has studied the political polarization phenomenon, most focus on the United States ...
Emilio Recart Zapata, Emilio Recart Zapata, Tomas Alves Salgueiro, Pablo Nicolas Fernández Larrosa, Pablo Nicolas Fernández Larrosa   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Familiarity Is the Kingdom of the Lost

This fictionalized, first-person biography tells how a cunning rogue with nothing to lose relies on his guts and wits to survive amid racism and injustice in apartheid South Africa.Intro -- Contents -- Figures -- Foreword -- Note on Names and Terminology
Simon, Barney., Lawrance, Benjamin N., Kumalo, Vusumuzi R., Gordimer, Nadine., Boetie, Dugmore.   +4 more
core  

Home-field advantage or a matter of ambiguity aversion? Local bias among German individual investors [PDF]

We analyze the effect of geographic proximity on individual investors' portfolio choice. Using a unique data set which covers the common stockholdings of private households at regional banks in Germany, we document strong and consistent overinvestment in
Stolper, Oscar, Walter, Andreas, Baltzer, Markus   +2 more
core  

Optimising the provision of health information for older adults across paper and screen formats - A requirement study with content producers and consumers.

PLOS Digital Health
The global shift toward digital health communication presents both opportunities and challenges for older adults, whose populations is expanding rapidly.
Larissa Taveira Ferraz, David Mark Frohlich, Charo Elena Hodgkins, Haiyue Yuan, Paula Costa Castro   +4 more
doaj   +1 more source

Less is more: towards a discrepancy in the representation of ‘no added sulphite’ wines among French professionals and consumers.

OENO One
As an emergent phenomenon in the wine market, ‘no added sulphite wines’ (NAS) are an ill-defined category for both consumers and professionals. This study aimed to identify the representation of NAS wines for French wine consumers and professionals and ...
Carole HONORE-CHEDOZEAU, Nathalie Pouzalgues, Ronan Symoneaux   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source