Results 101 to 110 of about 85,426 (286)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

In gratiam Judaeis: Plaiting a Message of Redemption from Borrowed Iconography

Sefarad : Revista de Estudios Hebraicos y Sefardíes
This article is a study of the way, a seemingly single margin figurative decoration in the Catalan Micrography Maḥzor (Jerusalem, NLI, Heb 8º6527) offers a multivalent reading of redemption.
Dalia-Ruth Halperin
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Impact of Content Familiarity on Reading Comprehension among Male and Female Students [PDF]

The current study investigated the impacts of content familiarity on the comprehension performance of male and female Saudi students. The study adopted the quantitative method and tested thirty-two male and female university students through two gender ...
Azmi, M. (Mohd ), Najadat, H. (Hamzah )
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Preparation for the Implementation of the International Classification of Diseases 11th Revision: A Survey on Clinical Coders' Knowledge of the International Classification of Diseases 11th Revision, Educational Needs, and Readiness to Accept New Roles: A Cross‐Sectional Study

Health Science Reports
Background and Aims Studies have shown that the knowledge and skills of clinical coders impact the quality of clinical coding, and professional training for clinical coders is essential to ensure coding quality.
Javad Zarei, AliMohammad Hadianfard, Abbas Sheikhtaheri   +2 more
doaj   +1 more source

Exploring fake news awareness and trust in the age of social media among university student TikTok users

Cogent Social Sciences
This study explores the awareness of fake news and trust dynamics among University students on TikTok. Utilizing qualitative research through semi-structured interviews with University students in Vietnam, the findings reveal a generally acknowledged ...
Duong Hoai Lan, Tran Minh Tung
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Using podcasts to bridge the gap between science communication and specialized scientific fields: a case study of mass spectrometry

Frontiers in Communication
This study aimed to evaluate the use of podcasts in disseminating specialized scientific fields, such as mass spectrometry. Four podcasts featuring interviews with researchers working with mass spectrometry were produced.
Nayyer Rehman, Nayyer Rehman, Victoria Edkins, Nives Ogrinc, Nives Ogrinc   +4 more
doaj   +1 more source