Results 91 to 100 of about 85,426 (286)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Familiarity impacts person perception [PDF]
, 2007 We investigated the effects of familiarity on person perception. We predicted that familiarity would increase non-analytic processing, reducing attention to and the impact of individuating information, and increasing the impact of category labels on ...
Garcia-Marques, Teresa, Mackie, Diane M.
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Social SciencesSeveral countries have adopted a nationwide ban on social media access for children. Our aim was to investigate public opinion regarding the implementation of a social media ban for children, as well as the factors influencing these views.
Petros Galanis +2 more
doaj +1 more source
, 2010 The influence of field based-experiences in K-12 classroom and grade level licensure area on preservice teachers’ attitudes, familiarity, use, and perceived applicability of content area reading instruction was examined for 597 participants from three ...
Davis, Bridgette LaDonna
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Fake News are Easier, More Emotional and Less Complex: Some Evidence from Spanish
Psychology of Language and CommunicationCharacterizing false information based on linguistic analysis is important to understand the factors that affect the proliferation of fake news in the media. Previous work has identified some linguistic regularities that suggest a trend towards decreased
Reali Florencia
doaj +1 more source
, 2012 The ability to comprehend expository text is vital for academic and professional success; however, many students struggle with this genre. While it has been found that text structure-based graphic organizers (GOs) may assist older students in ...
Anne Elizabeth Snyder +1 more
core +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source