Results 81 to 90 of about 4,786,818 (328)

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Guardians of digital safety: benchmarking large language models in the fight against online toxicity

Journal of Big Data
The extensive spread of harmful content, including hate speech, harassment, violent and adult material across online platforms and media channels poses significant challenges and has raised considerable concern within various societal groups.
Nouar AlDahoul, Myles Joshua Tan, Harishwar Reddy Kasireddy, Yasir Zaki   +3 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Fediverse Blocklists: Moderation in Noncapitalist Social Media

tripleC: Communication, Capitalism & Critique
Content moderation is a key form of labour on social media. While much of the scholarly attention has been given to paid or voluntary content moderation on corporate social media, this paper draws attention to content moderation on noncapitalist ...
Robert W Gehl
doaj   +1 more source

Online Extremism, AI, and (Human) Content Moderation

Feminist Philosophy Quarterly, 2022
This paper has three main goals: (1) to clarify the role of artificial intelligence (AI)—along with algorithms more broadly—in online radicalization that results in “real world violence,” (2) to argue that technological solutions (like better AI) are ...
Michael Randall Barnes
doaj  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Platforms, the First Amendment and Online Speech: Regulating the Filters [PDF]

, 2019
In recent years, online platforms have given rise to multiple discussions about what their role is, what their role should be, and whether they should be regulated. The complex nature of these private entities makes it very challenging to place them in a
Grafanaki, Sofia
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Auditing GPT's Content Moderation Guardrails: Can ChatGPT Write Your Favorite TV Show?

Conference on Fairness, Accountability and Transparency
Large language models (LLMs) are increasingly appearing in consumer-facing products. To prevent problematic use, the organizations behind these systems have put content moderation guardrails in place that prevent the models from generating content they ...
Yaaseen Mahomed, Charlie M. Crawford, Sanjana Gautam, Sorelle A. Friedler, Danaë Metaxa   +4 more
semanticscholar   +1 more source