Results 71 to 80 of about 223,072 (346)

Surviving an "Eternal September" - How an Online Community Managed a Surge of Newcomers

open access: yes, 2016
We present a qualitative analysis of interviews with participants in the NoSleep community within Reddit where millions of fans and writers of horror fiction congregate.
Hill, Benjamin Mako   +2 more
core   +1 more source

This Is Not a Myeloproliferative Neoplasm…

open access: yes
Pediatric Blood &Cancer, EarlyView.
Stephanie Juané Kennedy
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Guardians of digital safety: benchmarking large language models in the fight against online toxicity

open access: yesJournal of Big Data
The extensive spread of harmful content, including hate speech, harassment, violent and adult material across online platforms and media channels poses significant challenges and has raised considerable concern within various societal groups.
Nouar AlDahoul   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Fediverse Blocklists: Moderation in Noncapitalist Social Media

open access: yestripleC: Communication, Capitalism & Critique
Content moderation is a key form of labour on social media. While much of the scholarly attention has been given to paid or voluntary content moderation on corporate social media, this paper draws attention to content moderation on noncapitalist ...
Robert W Gehl
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Content moderation assistance through image caption generation

open access: yesIntelligent Systems with Applications
The rapid growth in digital media creation has led to an increased challenge in content moderation. Manual and automated moderation are susceptible to risks associated with a slower response time and false positives arising from unpredictable user inputs
Liam Kearns
doaj   +1 more source

Raging Against the Machine: Network Gatekeeping and Collective Action on Social Media Platforms

open access: yesMedia and Communication, 2017
Social media platforms act as networked gatekeepers—by ranking, channeling, promoting, censoring, and deleting content they hold power to facilitate or hinder information flows.
Sarah Myers West
doaj   +1 more source

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