Results 51 to 60 of about 1,238 (207)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Aspirational platform governance: How creators legitimise content moderation through accusations of bias

Internet Policy Review
While content moderation began as a solution to online abuse, it has increasingly been framed as a source of abuse by a diverse coalition of users, civil society organisations, and politicians concerned with platform bias.
Blake Hallinan, CJ Reynolds, Yehonatan Kuperberg, Omer Rothenstein   +3 more
doaj   +1 more source

The Urgency of Religious Moderation in Preventing Radicalism in Indonesia

Esensia: Jurnal Ilmu-Ilmu Ushuluddin, 2020
This paper aims to contribute to the thought of realizing religious moderation to prevent radicalism. The problem is, what is meant by religious moderation and how to do the deradicalization of religious moderation based harmony in Indonesia.
Arifinsyah Arifinsyah, Safria Andy, Agusman Damanik   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Chillbot: Content Moderation in the Backchannel

Proceedings of the ACM on Human-Computer Interaction
Moderating online spaces effectively is not a matter of simply taking down content: moderators also provide private feedback and defuse situations before they cross the line into harm. However, moderators have little tool support for these activities, which often occur in the backchannel rather than in front of the entire community.
Joseph Seering, Manas Khadka, Nava Haghighi, Tanya Yang, Zachary Xi, Michael S. Bernstein   +5 more
openaire   +3 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Pengutan Moderasi Beragama Berbasis Konten pada Organisasi IPNU-IPPNU

Kifah
Religious moderation is an important principle in maintaining social harmony that emphasizes balance, tolerance, and respect for differences amid religious and cultural diversity in Indonesia.
Siti Asiyah
doaj   +1 more source

Collaborative Content Moderation in the Fediverse

CoRR
The Fediverse, a group of interconnected servers providing a variety of interoperable services (e.g. micro-blogging in Mastodon) has gained rapid popularity. This sudden growth, partly driven by Elon Musk's acquisition of Twitter, has created challenges for administrators though.
Haris Bin Zia, Aravindh Raman, Ignacio Castro, Gareth Tyson   +3 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Trading nuance for scale? Platform observability and content governance under the DSA

Internet Policy Review
The Digital Services Act (DSA) marks a paradigmatic shift in platform governance, introducing mechanisms like the Statement of Reasons (SoRs) database to foster transparency and observability of platforms’ content moderation practices.
Charis Papaevangelou, Fabio Votta
doaj   +1 more source