Results 81 to 90 of about 223,072 (346)

Algorithmic content moderation: Technical and political challenges in the automation of platform governance

Big Data & Society, 2020
As government pressure on major technology companies builds, both firms and legislators are searching for technical solutions to difficult platform governance puzzles such as hate speech and misinformation.
Robert Gorwa, Reuben Binns, Christian Katzenbach   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The structure of optimism : "Controllability affects the extent to which efficacy beliefs shape outcome expectancies" [PDF]

, 2012
In this article we theoretically develop and empirically test an integrative conceptual framework linking dispositional optimism as general outcome expectancy to general efficacy beliefs about internal (self) and external (instrumental social support and
Monsen, Erik, Urbig, Diemo
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Konsep Dan Implementasi Moderasi Beragama dalam Ruang Digital

Afkaruna
Indonesia, as a multicultural country with various ethnicities, religions and races, faces challenges in maintaining tolerance amidst differences of opinion.
Fuadul Umam, R. Riski Dwi Koestanto
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Heteronormative Male Gaze: Experiences of Sexual Content Moderation Among Queer Instagram Users in Berlin

International Journal of Communication
Recent research suggests that social media moderation policies banning sexual content systematically disfavor LGBTQIA+ people. However, specific impacts on particular communities remain understudied.
Rachel Griffin
doaj  

A Misogynistic Glitch? A Feminist Critique of Algorithmic Content Moderation

Law, Technology and Humans
In recent years, all leading social media platforms have integrated artificial intelligence (AI) into their content moderation workflows. An increasingly prevalent narrative suggests that algorithms capable of detecting and removing prohibited or harmful
Valentina Golunova
doaj   +1 more source

TARGE: large language model-powered explainable hate speech detection [PDF]

PeerJ Computer Science
The proliferation of user-generated content on social networking sites has intensified the challenge of accurately and efficiently detecting inflammatory and discriminatory speech at scale. Traditional manual moderation methods are impractical due to the
Muhammad Haseeb Hashir, Memoona, Sung Won Kim   +2 more
doaj   +2 more sources