Results 181 to 190 of about 18,917,592 (282)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Identity, functional consequences, and context effects of amino acids inserted during suppression of CFTR nonsense mutations. [PDF]

open access: yesJ Cyst Fibros
Thrasher K   +9 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

The Context Institute

open access: yes
Access to back issues of the quarterly publication "In Context" is available through the site and explores a variety of topics surrounding sustainable ...

core  

Context effects: discourse structure influences narrative ability in autism and first-degree relatives. [PDF]

open access: yesFront Psychiatry
Landau E   +7 more
europepmc   +1 more source

Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells. [PDF]

open access: yesDNA Repair (Amst), 2021
Bacurio JHT   +7 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Quantum Logic of Semantic Space: An Exploratory Investigation of Context Effects in Practical Reasoning

open access: yes, 2005
This article is an exploratory account of the the non-monotonic behaviour of conceptual associations in the light of context. Computational approximations of conceptual space are furnished by semantic space models which are emerging from the fields of ...
Bruza, Peter D., Cole, Richard
core  

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