Results 181 to 190 of about 2,444,709 (292)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

What Is a Context? Linguistic Approaches and Challenges

Recent work on numerically-quantified expressions has aimed to identify which components of their meaning are semantic and which are pragmatic. Pragmatically-oriented accounts assign a crucial role to contextual factors, such as the level of information ...
Schumacher, Petra B., Finkbeiner, Rita., Meibauer, Jörg.   +2 more
core  

Quantum Logic of Semantic Space: An Exploratory Investigation of Context Effects in Practical Reasoning

, 2005
This article is an exploratory account of the the non-monotonic behaviour of conceptual associations in the light of context. Computational approximations of conceptual space are furnished by semantic space models which are emerging from the fields of ...
Bruza, Peter D., Cole, Richard
core  

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Context effects in social and psychological research

, 2010
Contents: Part 1. Introduction and historical overview – Norbert Schwarz, Seymour Sudman: Introduction (3-4); Howard Schuman: Context effects: state of the past/ state of the art (5-20). Part II.

core  

Context effects: discourse structure influences narrative ability in autism and first-degree relatives. [PDF]

Front Psychiatry
Landau E, Nayar K, Martin GE, Stevens C, Xing J, Guilfoyle J, Lau JCY, Losh M.   +7 more
europepmc   +1 more source

Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells. [PDF]

DNA Repair (Amst), 2021
Bacurio JHT, Yang H, Naldiga S, Powell BV, Ryan BJ, Freudenthal BD, Greenberg MM, Basu AK.   +7 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Evaluating context effects on PHQ-8 somatic item scores among people with a chronic medical condition: a scleroderma patient-centred intervention network randomised experiment. [PDF]

Epidemiol Psychiatr Sci
Hu S, Carrier ME, Golberg M, Geoffroy MC, Kwakkenbos L, Bartlett SJ, Fortuné C, Gietzen A, Gottesman K, Lawrie-Jones A, Malcarne VL, Richard M, Sauvé M, Mouthon L, Benedetti A, Thombs BD, SPIN Investigators.   +16 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source