Results 41 to 50 of about 564,745 (245)

Impact of Public Transport Context Situation and Culture on Mode Choice

Social Sciences, 2019
Arrival on time when reaching a trip destination is perceived differently by different communities, but the need to arrive at the desired time is essential.
Miguel Loyola, Yoram Shiftan, Haim Aviram, Hector Monterde-i-Bort   +3 more
doaj   +1 more source

Social and demographic aspects of women’s situation in Ukraine in the context of CEDAW

Український соціум, 2020
This paper dwells upon the demographic features and some peculiarities of women’s social situation in Ukraine in the context of CEDAW’s requirements. It also reviews the implementation of these requirements in recent years.
Kurylo I. O.
doaj   +1 more source

THE CONTEXT OF SITUATION AND CONTEXT OF CULTURE (GENRE) IN THE VIDEO TUTORIALS ON YOUTUBE CHANNEL: A FUNCTIONAL DISCOURSE APPROACH

Social Sciences, Humanities and Education Journal, 2022
This study examines the contexts of the videos in YouTube videos of Devina Hermawan. In examining the contexts of the videos, the researcher adopts Halliday’s systemic functional linguistics (SFL).
Atina Firdausa Qisthi, Sigit Ricahyono, Tri Wahyuni Chasanatun   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Les rôles du co-texte, du contexte et de la situation dans la lecture en langue étrangère et leur implication pour la lexicographie bilingue

Corela, 2012
This study aims to identify co-text, context, and situation roles in the construction of meaning in reading by putting into practice a pedagogical approach during French for Specific Purposes classes.
Sandra Dias Loguercio
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RHETORIC IN THE CONTEXT OF THE POST-TRUTH SITUATION

Епістемологічні дослідження у філософії, соціальних і політичних науках
This article analyzes the origins and significance of rhetoric as an effective means of control through modal power exercised by free citizens of the classical Athenian polis.
Вадим ПАЛАГУТА
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source