Results 41 to 50 of about 601,139 (216)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

RHETORIC IN THE CONTEXT OF THE POST-TRUTH SITUATION

Епістемологічні дослідження у філософії, соціальних і політичних науках
This article analyzes the origins and significance of rhetoric as an effective means of control through modal power exercised by free citizens of the classical Athenian polis.
Вадим ПАЛАГУТА
doaj   +1 more source

Structure of a Psychotherapeutic Situation in the Context of the Orthodox-oriented Approach

Консультативная психология и психотерапия, 2015
The article introduces a model of a psychotherapeutic situation structure in the context of the Orthodox-oriented approach, which helps a psychologist to consider spiritual reality in psychotherapeutic case analysis.
Drozdov D.S.
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Social and demographic aspects of women’s situation in Ukraine in the context of CEDAW

Український соціум, 2020
This paper dwells upon the demographic features and some peculiarities of women’s social situation in Ukraine in the context of CEDAW’s requirements. It also reviews the implementation of these requirements in recent years.
Kurylo I. O.
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Context Flow Graphs: Situation Modeling for Rule-Based Proactive Context-Aware Systems

IEEE Access, 2020
A proactive context-aware system automatically adapts its user interface to the user's situational needs. This is achieved by continuously capturing the environmental properties, reasoning upon the context, and detecting situations where unsolicited ...
Sandro Rodriguez Garzon, Bernd Louis
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evidence of audience in MS Hunter 93, a medical text

Revista de Lenguas para Fines Específicos, 2015
The aim of this paper is to explore the concept and evidence of audience in the text of MS Hunter 93 (T.4.10), a remedy book written in the second half of the 16th century (c.a. 1565).
Ivalla Ortega Barrera
doaj