Results 41 to 50 of about 583,292 (317)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

J.-P. SARTRE’S HUMANISM IN THE CONTEXT OF MODERN ANTHROPOLOGICAL SITUATION

Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2019
Purpose. The article is aimed to show the specificity and heuristic value of the humanism of the French existentialist J.-P. Sartre, represented both in his early works, where the isolationist position prevailed, and considering his evolution to various ...
V. V. Liakh, M. I. Khylko
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RESILIENCE IN THE CONTEXT OF THE SOCIO-POLITICAL SITUATION OF YOUNG ADULTS IN EUROPE

Humanities and Social Sciences, 2023
As the epidemiological statistics for anxiety disorders and mood disorders show, adult mental health has declined in recent decades, making the life of the average person more prone to adversity.
Agnieszka FRANCZOK-KUCZMOWSKA, Barbara SUPERSON   +1 more
doaj   +1 more source

The rubric as an assessment tool for solving problem situations in the physics and mathematics teaching context [PDF]

, 2021
J Salazar-Torres, O Rincón Leal, M Vergel Ortega   +2 more
openalex   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Impact of Public Transport Context Situation and Culture on Mode Choice

Social Sciences, 2019
Arrival on time when reaching a trip destination is perceived differently by different communities, but the need to arrive at the desired time is essential.
Miguel Loyola, Yoram Shiftan, Haim Aviram, Hector Monterde-i-Bort   +3 more
doaj   +1 more source

THE CONTEXT OF SITUATION AND CONTEXT OF CULTURE (GENRE) IN THE VIDEO TUTORIALS ON YOUTUBE CHANNEL: A FUNCTIONAL DISCOURSE APPROACH

Social Sciences, Humanities and Education Journal, 2022
This study examines the contexts of the videos in YouTube videos of Devina Hermawan. In examining the contexts of the videos, the researcher adopts Halliday’s systemic functional linguistics (SFL).
Atina Firdausa Qisthi, Sigit Ricahyono, Tri Wahyuni Chasanatun   +2 more
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source