Results 71 to 80 of about 1,119,807 (246)

Socio-economic parameters of functions of the territory of territorial communities in the context of spatial planning

Zemleustrìj, Kadastr ì Monìtorìng Zemelʹ, 2022
The existing methods and parameters for determining the capacity and monitoring the development of territorial communities in ecological, economic and social sections are analysed.
O. Dorosh, A. Dorosh, I.-O. Zastulka
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Selection of optimal tree top detection parameters in a context of effective forest management

Economics and Environment, 2019
In the process of tree stand parameter estimation based on data from airborne laser scanning ALS, the detection of a single tree is an important starting point.
Łukasz Kolendo, Marek Ksepko
doaj  

Urban Canopy Parameters’ Computation and Evaluation in an Indian Context Using Multi-Platform Remote Sensing Data

Urban Science
Urban Canopy Parameters (UCPs) are crucial for urban microclimate modeling; however, the scarce availability of precise UCP data in developing regions limits their application for urban climates.
Kshama Gupta, Bhoomika Ghale, Ashutosh Bhardwaj, Anshika Varshney, Shweta Khatriker, Vinay Kumar, Prasun Kumar Gupta, Pramod Kumar   +7 more
doaj   +1 more source

Equivalence of Context and Parameter Updates in Modern Transformer Blocks

CoRR
Recent research has established that the impact of context in a vanilla transformer can be represented implicitly by forming a token-dependent, rank-1 patch to its MLP weights. This work extends that foundational theory to the diverse architectures of modern Large Language Models.
Adrian Goldwaser, Michael Munn, Javier Gonzalvo, Benoit Dherin   +3 more
openaire   +2 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

On the issue of analyzing psychological well-being in the context of personal and demographic parameters

Психологическая наука и образование
Context and relevance. The mental well-being of the population is a critical issue in modern society. Big data technologies offer new opportunities for identifying factors that influence a person's psychological state, while minimizing the ...
N.Yu. Gomziakova, P.A. Kovalev, L.A. Kovalkova, A.A. Kochkarov   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source