Results 71 to 80 of about 1,117,339 (246)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Socio-economic parameters of functions of the territory of territorial communities in the context of spatial planning

Zemleustrìj, Kadastr ì Monìtorìng Zemelʹ, 2022
The existing methods and parameters for determining the capacity and monitoring the development of territorial communities in ecological, economic and social sections are analysed.
O. Dorosh, A. Dorosh, I.-O. Zastulka
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Selection of optimal tree top detection parameters in a context of effective forest management

Economics and Environment, 2019
In the process of tree stand parameter estimation based on data from airborne laser scanning ALS, the detection of a single tree is an important starting point.
Łukasz Kolendo, Marek Ksepko
doaj  

On the issue of analyzing psychological well-being in the context of personal and demographic parameters

Психологическая наука и образование
Context and relevance. The mental well-being of the population is a critical issue in modern society. Big data technologies offer new opportunities for identifying factors that influence a person's psychological state, while minimizing the ...
N.Yu. Gomziakova, P.A. Kovalev, L.A. Kovalkova, A.A. Kochkarov   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Urban Canopy Parameters’ Computation and Evaluation in an Indian Context Using Multi-Platform Remote Sensing Data

Urban Science
Urban Canopy Parameters (UCPs) are crucial for urban microclimate modeling; however, the scarce availability of precise UCP data in developing regions limits their application for urban climates.
Kshama Gupta, Bhoomika Ghale, Ashutosh Bhardwaj, Anshika Varshney, Shweta Khatriker, Vinay Kumar, Prasun Kumar Gupta, Pramod Kumar   +7 more
doaj   +1 more source

A Hybrid Approach to Monitor Context Parameters for Optimising Caching for Context-Aware IoT Applications

Internet of Things (IoT) has seen a prolific rise in recent times and provides the ability to solve several key challenges faced by our societies and environment. Data produced by IoT provides a significant opportunity to infer context that is key for IoT applications to make decisions/actuations.
Ashish Manchanda, Prem Prakash Jayaraman, Abhik Banerjee, Arkady B. Zaslavsky, Shakthi Weerasinghe, Guang-Li Huang   +5 more
openaire   +2 more sources