Results 81 to 90 of about 1,117,339 (246)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Context management: toward assessing quality of context parameters in a ubiquitous ambient assisted living environment

Journal of Information Systems and Technology Management, 2014
This paper provides an approach to assessing Quality of Context (QoC) parameters in a ubiquitous Ambient Assisted Living (AAL) environment. Initially, the study presents a literature review on QoC, generating taxonomy. Then it introduces the context management architecture used. The proposal is verified with the Siafu simulator in an AAL scenario where
Nazario, Debora Cabral, Dantas, Mario Antonio Ribeiro, Todesco, Jose Leomar   +2 more
openaire   +3 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Adaptive Measurement of Change in the Context of Item Parameter Drift

Applied Psychological Measurement
Adaptive measurement of change (AMC) uses computerized adaptive testing (CAT) to measure and test the significance of intraindividual change on one or more latent traits. The extant AMC research has so far assumed that item parameter values are constant across testing occasions.
Allison W. Cooperman, Ming Him Tai, Joseph N. DeWeese, David J. Weiss   +3 more
openaire   +2 more sources

Context-Aware Parameter Estimation for Forecast Models in the Energy Domain

, 2011
Continuous balancing of energy demand and supply is a fundamental prerequisite for the stability and efficiency of energy grids. This balancing task requires accurate forecasts of future electricity consumption and production at any point in time. For this purpose, database systems need to be able to rapidly process forecasting queries and to provide ...
Lars Dannecker, Robert Schulze, Matthias Böhm 0001, Wolfgang Lehner, Gregor Hackenbroich   +4 more
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Integrated analysis of geofiltrational parameters in the context of underground coal gasification relying upon calculations and modeling

E3S Web of Conferences, 2018
Objective of the paper is to substantiate and implement the integrated approach aimed at the studies of filtration and mass-transfer processes within roof rocks of coal seams in the context of their underground gasification.
Inkin Oleksandr, Tishkov Volodymyr, Dereviahina Nataliia, Sotskov Vadym   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

NOISYICL: A Little Noise in Model Parameters Calibrates In-context Learning

CoRR
20 pages, 28 figures, 7 tables (5 pages, 4 figures, 1 table in main body).
Yufeng Zhao, Yoshihiro Sakai, Naoya Inoue   +2 more
openaire   +2 more sources