Results 111 to 120 of about 1,493,771 (318)
Les transformations actuelles de l’EEE
Mesure et Évaluation en Éducation, 2012 Dans cet article conclusif, les transformations actuelles de l’EEE sont interrogées selon trois axes. Les limites et les dérives observées dans ce domaine conduisent tout d’abord à remettre en question une approche de la qualité de l’enseignement ...
Nathalie Younès, Marc Romainville
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Introduction: Contexts of Violence in Comics [PDF]
, 2020 This book is part of a nuanced two-volume examination of the ways in which violence in comics is presented in different texts, genres, cultures and contexts. Contexts of Violence in Comics asks the reader to consider the ways in which violence and its
Mickwitz, Nina, Hague, Ian, Horton, Ian
core
Formalized Mathematics, 2014 Summary Two construction functors: simple term with a variable and compound term with an operation and argument terms and schemes of term induction are introduced. The degree of construction as a number of used operation symbols is defined. Next, the term context is investigated. An x-context
openaire +3 more sources
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Revue Archéologique du Centre de la France, 2009 An important body of all types of craft industries has been built up for the Roman period and is accessible here in context: it concerns the whole of the Lyonnaise Roman province (from Finistère to Lyonnais) as well as the cities of the north and of ...
Alain Ferdière
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