Aberrant Splicing Signatures Underpin Oligodendrocyte Damage in ALS and Neuron Loss in FTD
Advanced Science, EarlyView.Integrating bulk and single‐nucleus RNA‐seq from ALS and FTD patients, we revealed distinct cellular dysfunctions, with severe oligodendrocyte damage in ALS and pronounced neuron loss in FTD. We identified cell‐type‐specific aberrant splicing events as potential biomarkers with robust classification performance, some of which produce de novo peptides ...
Chen Du +6 more
wiley +1 more source
What Do Respondents Bring to Contingent Valuation? A Comparison of Monetary and Labor Payment Vehicles [PDF]
With contingent valuation, both the goods being valued and the payment vehicles used to value them are mostly hypothetical. However, although numerous studies have examined the impact of experience with the good on willingness to pay, less attention has ...
Eggert, Hakan +3 more
core
Willingness to pay for a National Health Insurance Scheme in The Gambia: a contingent valuation study. [PDF]
Health Policy Plan, 2023 Njie H +6 more
europepmc +1 more source
Discovery of SKP2‐Recruiting PROTACs for Target Protein Degradation
Advanced Science, EarlyView.Based on the SKP2‐targeting ligand SL1, we designed non‐covalent PROTACs by linking it with the BRD4 inhibitor JQ1 and the AR antagonist AL through a linker. These PROTACs successfully induced the ubiquitination of BRD4 and AR, followed by proteasome‐mediated degradation.
Guanjun Dong +13 more
wiley +1 more source
Contingent valuation and cultural policy design: The case of "Napoli Musei Aperti"
, 1998 The aim of the paper is twofold: to carry out a contingent valuation study of "Napoli Musei Aperti", a cultural public good provided by the city of Naples, and to explore some alternative schemes of cultural policy. The paper is divided in two parts.
Santagata, Walter, Signorello, Giovanni
core +1 more source
Women's Preference for Cervical Cancer Screening Methods in Iran: A Contingent Valuation Survey. [PDF]
Med J Islam Repub Iran, 2022 Shokri Jamnani ASJ +3 more
europepmc +1 more source
Advanced Science, EarlyView.The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang +7 more
wiley +1 more source
Respondent incentives in contingent valuation: The role of reciprocity [PDF]
--public expenditures,environmental valuation,cost-benefit analysis,contingent valuation method,respondent incentives,reciprocity ...
Ahlheim, Michael +2 more
core
Justify or die? - using contingent valuation of service provision in a UK public library [PDF]
, 2006 The public library service in the UK is currently under pressure to justify its existence. An Audit Commission report suggested that if current borrowing rates for libraries continue into the future, libraries would be effectively issuing no books by ...
McGettigan, L. +2 more
core
Estimating the cost-effectiveness threshold of advanced non-small cell lung cancer in China using mean opportunity cost and contingent valuation method. [PDF]
Cost Eff Resour Alloc, 2023 Peng Q +8 more
europepmc +1 more source