Results 61 to 70 of about 82,184 (301)

Change and Our Commitment to Continual Improvement

Journal of the ASEAN Federation of Endocrine Societies, 2017
After six years of continuous, regular and timely publication of high quality endocrinology articles from the Southeast Asian region, we are pleased to announce that JAFES is now indexed in Scopus, one of the largest abstract and citation databases of peer-reviewed literature. Along with our efforts of adopting international standards, shifting to 100%
openaire   +4 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

(No) influence of continuous integration on the commit activity in GitHub projects [PDF]

Proceedings of the 4th ACM SIGSOFT International Workshop on Software Analytics, 2018
A core goal of Continuous Integration (CI) is to make small incremental changes to software projects, which are integrated frequently into a mainline repository or branch. This paper presents an empirical study that investigates if developers adjust their commit activity towards the above-mentioned goal after projects start using CI.
Sebastian Baltes, Jascha Knack, Daniel Anastasiou, Ralf Tymann, Stephan Diehl 0001   +4 more
openaire   +2 more sources

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

The relationship between organizational commitment and staff performances in a health care network

Payesh, 2012
Objective (s): To measure the relationship between organizational commitment of "Marand Health and Treatment Network" and their performance in Iran, 2010.Methods: The research has been a cross-sectional one of correlation type, which has been carried out
Iravan Masoodi Asl, Kamran Haji Nabi, Farhad Nosartinejad, Habibollah Sodaei   +3 more
doaj  

Checking the healthiness of commitment profile from its prediction of burnout [PDF]

, 2010
no. 443This paper examines the commitment profiles of Hong Kong Chinese architecture students with the 3-factor model of professional commitment and its impact on burnout.
Jia, Y, Kvan, T, Lingard, H, Rowlinson, S, Yip, B   +4 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Escala de compromisso organizacional - Afectivo, Normativo e de Continuidade (ECO-ANC) [PDF]

, 2011
A escala de compromisso organizacional (Affectíve, Normative and Continuance Commitment Scales. no original) de Meyer eAllen (1991, 997; Allen, &Meyer, 1990) visa avaliar a relação de vinculação que o trabalhador estabelece com a organização onde ...
Martins, Helena, Rebelo, Teresa, Tomás, Inês   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source