Results 71 to 80 of about 81,762 (303)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
How does trust in leader influences organizational commitment? A test of a moderated mediation model
Acta PsychologicaThis study examines the link between trust in leader, employee silence, and affective, normative, and continuance organizational commitment. Additionally, this study analyzes how employee silence mediates the link between trust in leader and ...
Savita S Rai, Navin Kumar Koodamara
doaj +1 more source
, 2017 The description of plasma using fluid model is mostly insufficient and requires the consideration of velocity distribution which leads to kinetic theory.
Ali, Jalil +3 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Jurnal Psikologi, 2015 The purpose of this research was to investigate the influence of social support and transformational leadership toward the three component model of organizational commitment (affective, continuance, and normative) with work motivation as a mediator ...
Miftahun Ni’mah Suseno, - Sugiyanto
doaj +1 more source
Media Riset Bisnis & Manajemen, 2007 Although research the determinant of service provides switching has grown in recent years, the focus has been predominantly on transactional, not relational variables. In this research, the authors address the role of customer commitment on customers' intentions to switch.
openaire +1 more source
Achieving Value Co-creation in IT Outsourcing [PDF]
, 2016 Over the past few decades, information technology outsourcing has become a widely used and researched means for enterprises to enhance their performance. As future collaboration is the most desirable outcome between enterprises and IT outsourcing vendors,
Chen, Li-Shan, Sun, Szu-Yuan
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The relationship between self-construal, job satisfaction and organizational commitment [PDF]
, 2016 This study aimed to investigate the relationship between self-construal, job satisfaction and organizational commitment among young working adults in Malaysia.
Abdullah, Haslinda, Mun, Wong Swee
core