Results 121 to 130 of about 1,237,080 (283)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

On the numerical stability of the branched continued fraction expansion of the ratio $H_4(a,d+1;c,d;\mathbf{z})/H_4(a,d+2;c,d+1;\mathbf{z})$

Математичні Студії
Continued fractions and their generalization, branched continued fractions, are the effective tools used to study special functions. In this aspect, an important problem of continued fractions and branched continued fractions is the study of their ...
M. V. Dmytryshyn, C. Cesarano, O. Kondur, I.-A. Lutsiv   +3 more
doaj   +1 more source

Continued Fractions and Factoring

, 2019
Legendre found that the continued fraction expansion of $\sqrt N$ having odd period leads directly to an explicit representation of $N$ as the sum of two squares. Similarly, it is shown here that the continued fraction expansion of $\sqrt N$ having even period directly produces a factor of a composite $N$.
openaire   +3 more sources

On the relationship between generalised continued fractions and G-continued fractions

Journal of Computational and Applied Mathematics, 1990
Generalised continued fractions, or n-fractions, were used by \textit{M. G. de Bruin} [Generalized continued fractions and a multidimensional Padé table, Thesis (Amsterdam, 1974; Zbl 0273.41028)] in the study of simultaneous rational approximation of functions using rational functions with a common denominator.
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Hankel determinants and Jacobi continued fractions for $q$-Euler numbers

Comptes Rendus. Mathématique
The $q$-analogs of Bernoulli and Euler numbers were introduced by Carlitz in 1948. Similar to recent results on the Hankel determinants for the $q$-Bernoulli numbers established by Chapoton and Zeng, we perform a parallel analysis for the $q$-Euler ...
Chern, Shane, Jiu, Lin
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source