Results 41 to 50 of about 8,918,982 (409)

Evaluation of the Hemostatic Activity of Multicomponent Polymer Sponge Implants in An In Vitro Experiment

Неотложная медицинская помощь
BACKGROUND. The development of new samples of local hemostatic agents is an intensively developing area of the modern industrial biotechnology due to a high need of clinical bases for such products.
V. A. Lipatov, S. V. Lazarenko, D. A. Severinov, A. A. Denisov, O. V. Padalkina   +4 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Awareness, utilization and influencing factors of social supports for main informal caregivers of schizophrenia patients: a cross-sectional study in primary care settings in Beijing, China

BMC Family Practice, 2020
Background Most schizophrenia patients are supported by main informal caregivers at home in China. This study aims to investigate the further needs of social supports for main informal caregivers of schizophrenia patients and to analyze influencing ...
Meirong Wang, Guanghui Jin, Yun Wei, Feiyue Wang, Zhaolu Pan, Lifen Chen, Xiaoqin Lu   +6 more
doaj   +1 more source

Mandatory Continuing Education: Does It Really Protect Society from Incompetent Health Professionals [PDF]

, 1990
Although the focus is narrow, this article argues that, in the face of short half-lives of current knowledge, continuing education requirements are needed and suggests possible improvements in the way that continuing education is implemented.
McPartland, Patricia A.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Frequency and risk factors of fractures in adolescents and young ADULTS in the population of Irkutsk

Acta Biomedica Scientifica, 2016
The aim of the study was to examine frequency and risk factors of fractures among adolescents and young adults of Irkutsk aged 14 to 24. The results of the study showed that the frequency of fractures was 23.8 %; and boys have fractures significantly ...
L. S. Dats, L. V. Menshikova, A. V. Dats
doaj   +1 more source

Factors Hampering the Participation of Nursing Staff in the Continuing Education Activities of Hospitals Centers in the Casablanca-Settat Region [PDF]

, 2021
Amina Lhbibani, Abderrahmane Lamiri, Saïd Lotfi, Malika Tridane, Saïd Belaaouad   +4 more
openalex   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Analysis of health service utilization of migrants in Beijing using Anderson health service utilization model

BMC Health Services Research, 2018
Background Migrants are the unique production of China’s urbanization process. They are often excluded from social welfare and security systems of cities, and often exposed to high health risk related closely to their health problems.
Shuang Shao, Meirong Wang, Guanghui Jin, Yali Zhao, Xiaoqin Lu, Juan Du   +5 more
doaj   +1 more source