Results 61 to 70 of about 8,697,543 (404)

A Model for Predicting the Risk of Developing Drug-Induced Liver Injury During Therapy with Favipiravir

Антибиотики и Химиотерапия
Favipiravir is an antiviral drug that has become widely used for the etiotropic treatment of COVID-19. According to a number of studies, the incidence of adverse reactions during favipiravir therapy reaches 93%, and the most common adverse reaction is an
Yu. V. Shevchuk, I. V. Sychev, A. V. Kryukov, I. I. Temirbulatov, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev   +10 more
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Predicting the risk of developing drug-induced liver injury during remdesivir therapy in COVID-19 patients using machine learning

Acta Biomedica Scientifica
Background. The antiviral drug Remdesivir has been widely used for etiotropic treatment of COVID-19. The incidence of adverse reactions during Remdesivir therapy reaches 66.2 %, the most common one being an increase in hepatic transaminases.The aim.
Yu. V. Shevchuk, I. I. Shamigulov, I. V. Sychev, A. V. Kryukov, I. I. Temirbulatov, K. B. Mirzaev, N. P. Denisenko, Sh. P. Abdullaev, S. N. Tuchkova, V. I. Vechorko, O. V. Averkov, D. A. Sychev   +11 more
doaj   +1 more source

Acute mesenteric ischemia (clinical cases)

Acta Biomedica Scientifica, 2016
Acute mesenteric ischemia is one of the most severe pathological conditions in terms of its course and prognosis. In the case of bowel infarction it is accompanied by an extremely high fatality rate.
L. K. Kulikov, Y. A. Privalov, A. L. Mikhaylov, A. V. Kalinichenko, V. F. Sobotovich, A. A. Smirnov   +5 more
doaj   +1 more source

Governor\u27s Approval 12/13/1999 [PDF]

, 1999
The continuing problem of how to fund public education remains the most important problem facing the Granite State.
Survey Center, UNH
core   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

PREVALENCE OF THE DISEASES OF OSTEOMUSCULAR SYSTEM AND FRACTURES AMONG THE PERSONS OF YOUNG AGE IN IRKUTSK

Acta Biomedica Scientifica, 2012
The purpose of a research was the study of the frequency of arthralgia, prevalence of the diseases of osteomuscular system, and fractures among the persons from 14 to 24 years in Irkutsk. The frequency of arthralgia composed. 22,4 %.
L. S. Dats, L. V. Menshikova, E. B. Babanskaya, M. L. Menshikov   +3 more
doaj  

Association between social capital and utilization of essential public health services among elderly migrants: a multilevel logistic study based on the 2017 China migrant dynamic survey (CMDS)

BMC Public Health
Background As the number of elderly migrants in China continues to grow, it is necessary to pay closer attention to their health and health services. Some studies have confirmed that social capital plays a significant role in the utilization of health ...
Qi Luo, Xiaolei Chen, Linlin Zhao, Qinghua Hu, Juan Du, Shuang Shao   +5 more
doaj   +1 more source

Adult learners’ perceptions of self-directed learning and digital technology usage in continuing professional education: An update for the digital age

Journal of Adult and Continuing Education, 2019
Mandatory continuing professional education is accepted across many professions as a re-credentialing mechanism to maintain professional competency. Self-directed learning is a widely recognized type of learning to meet mandatory continuing professional ...
V. Curran, Diana L. Gustafson, K. Simmons, H. Lannon, Chenfang Wang, Mahyar Garmsiri, Lisa J. Fleet, Lyle R. Wetsch   +7 more
semanticscholar   +1 more source