Results 111 to 120 of about 584,519 (316)
More continuity than change: Kent's Tudor almshouses [PDF]
, 2021 As Nigel Goose and others have noted, early modern almshouses have received far less scholarly attention than medieval hospitals. This is beginning to be addressed and this study of Kent's Tudor almshouses shows the importance of regional studies to ...
Sweetinburgh, S.
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Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Continuity of the payoff function revisited [PDF]
The payoff function is defined on the product of the spaces of mixed strategies that are the spaces of probability measures on compact Hausdorff spaces. The continuity of the payoff function is recently proved by Glycopantis and Muir.
Michael Zarichnyi
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Is midwifery continuity of care cost effective?
, 2019 Midwifery Continuity of Care is a robust 'how to' guide to establishing midwifery continuity of care. Written by a team of international experts in their field, this book highlights lessons learned to help develop new ways of planning, implementing ...
Donnellan - Fernandez, Roslyn +3 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
ANALYSES OF FAMILY OWNED ENTERPRISE’S CONTINUITY (CASE STUDY OF FOUR FAMILY OWNED ENTERPRISE IN JAKARTA) [PDF]
Innovative Issues and Approaches in Social Sciences, 2013 The purpose of this study is to examine the roles that have an influence on the Family-Owned Enterprise (FOE) succession. This issue is raised because of the transition phenomena that occur between generations of the FOE, is interesting to study ...
Anita Maharani +2 more
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