Results 31 to 40 of about 198,076 (205)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Povezovanje tvarnih in pisanih virov pri proučevanju zgodnjega srednjega veka alpskih Slovanov

open access: yesArheološki Vestnik, 1979
Our knowledge of the Early Middle Ages (Alpine Slavs) leans almost exclusively on the basis of evidence supplied by written sources. For a good many years now the number of these sources has not changed and so knowledge of this period has stagnated ...
Andrej Pleterski
doaj  

Boundary regularity for elliptic systems under a natural growth condition [PDF]

open access: yes, 2010
We consider weak solutions $u \in u_0 + W^{1,2}_0(\Omega,R^N) \cap L^{\infty}(\Omega,R^N)$ of second order nonlinear elliptic systems of the type $- div a (\cdot, u, Du) = b(\cdot,u,Du)$ in $\Omega$ with an inhomogeneity satisfying a natural growth ...
Beck, Lisa
core   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

open access: yesFEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig   +7 more
wiley   +1 more source

Less than perfect quantum wavefunctions in momentum-space: How phi(p) senses disturbances in the force

open access: yes, 2010
We develop a systematic approach to determine the large |p| behavior of the momentum-space wavefunction, phi(p), of a one-dimensional quantum system for wich the position-space wavefunction, psi(x), has a discontinuous derivative at any order.
M. Belloni   +2 more
core   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

open access: yesFEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Remote Monitoring in Myasthenia Gravis: Exploring Symptom Variability

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is a rare, autoimmune disorder characterized by fluctuating muscle weakness and potential life‐threatening crises. While continuous specialized care is essential, access barriers often delay timely interventions. To address this, we developed MyaLink, a telemedical platform for MG patients.
Maike Stein   +13 more
wiley   +1 more source

‘What are the Gods to us now?’: secular theology and the modernity of law [PDF]

open access: yes, 2007
Integrating responses of Nietzsche to the death of God with classic instances of modernist political theory, a constituent parallel is drawn between monotheistic religion and modern law — a parallel in that each matches the other, but a parallel also in ...
Fitzpatrick, Peter
core  

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