Results 91 to 100 of about 18,593,943 (305)

Stability of interval positive continuous-time linear systems [PDF]

open access: yesBulletin of the Polish Academy of Sciences: Technical Sciences, 2018
T. Kaczorek
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Time-Continuous Hemispherical Urban Surface Temperatures

open access: yesRemote Sensing, 2017
Traditional methods for remote sensing of urban surface temperatures (Tsurf) are subject to a suite of temporal and geometric biases. The effect of these biases on our ability to characterize the true geometric and temporal nature of urban Tsurf is ...
Michael A. Allen   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Five Years of Continuous-time Random Walks in Econophysics [PDF]

open access: yes
This paper is a short review on the application of continuos-time random walks to Econophysics in the last five years.Duration; Continuous-time random walk; Fractional calculus; Statistical ...
Enrico Scalas
core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Estimating continuous-time income models [PDF]

open access: yes
While earning processes are commonly unobservable income flows which evolve in continuous time, observable income data are usually discrete, having been aggregated over time.
Schluter, Christian, Trede, Mark
core  

Stochastic differential utility as the continuous-time limit of recursive utility [PDF]

open access: yes, 2013
We establish a convergence theorem that shows that discrete-time recursive utility, as developed by Kreps and Porteus (1978), converges to stochastic differential utility, as introduced by Dufffie and Epstein (1992), in the continuous-time limit of ...
Seifried, Frank Thomas, Kraft, Holger
core   +1 more source

Continuous-Time Sparse Signal Recovery

open access: yesIEEE Access
This study investigates a continuous-time method for sparse signal recovery, which is suitable for analog optical circuit implementation. The proposed method is defined by a nonlinear ordinary differential equation (ODE) derived from the gradient flow ...
Tadashi Wadayama, Ayano Nakai-Kasai
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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