Results 1 to 10 of about 5,206,546 (317)

3D molecular phenotyping of cleared human brain tissues with light-sheet fluorescence microscopy

open access: yesCommunications Biology, 2022
An optimized clearing approach, named SHORT, applied to thick sections of human cortical tissue allows reconstruction of large portions of the tissues using light-sheet fluorescence microscopy, by performing multicolor immunostaining and multirounds.
Luca Pesce   +11 more
doaj   +1 more source

Assessing brain state and anesthesia level with two-photon calcium signals

open access: yesScientific Reports, 2023
Brain states, such as wake, sleep, or different depths of anesthesia are usually assessed using electrophysiological techniques, such as the local field potential (LFP) or the electroencephalogram (EEG), which are ideal signals for detecting activity ...
Núria Tort-Colet   +5 more
doaj   +1 more source

α-catenin switches between a slip and an asymmetric catch bond with F-actin to cooperatively regulate cell junction fluidity

open access: yesNature Communications, 2022
By using laser tweezers, the authors show that a single α-catenin molecule does not resist force on F-actin. However, clustering of multiple molecules and force applied toward F-actin pointed end engage a molecular switch in α-catenin, which unfolds and ...
C. Arbore   +8 more
doaj   +1 more source

Autofluorescence enhancement for label-free imaging of myelinated fibers in mammalian brains

open access: yesScientific Reports, 2021
Analyzing the structure of neuronal fibers with single axon resolution in large volumes is a challenge in connectomics. Different technologies try to address this goal; however, they are limited either by the ineffective labeling of the fibers or in the ...
Irene Costantini   +11 more
doaj   +1 more source

A Software Architecture to Mimic a Ventricular Tachycardia in Intact Murine Hearts by Means of an All-Optical Platform

open access: yesMethods and Protocols, 2019
Optogenetics is an emerging method that uses light to manipulate electrical activity in excitable cells exploiting the interaction between light and light-sensitive depolarizing ion channels, such as channelrhodopsin-2 (ChR2).
Francesco Giardini   +5 more
doaj   +1 more source

A global perspective on western Mediterranean precipitation extremes

open access: yesnpj Climate and Atmospheric Science, 2022
The Mediterranean region has been declared a climate change hotspot due, among other reasons, to an expected increase in the torrential rains that frequently affect this densely populated area.
Damián Insua-Costa   +3 more
doaj   +1 more source

Response Measurements on an Echinodome Subjected to Explosive Loading

open access: yesShock and Vibration, 1999
Free field explosion experiments were carried out to determine the general characteristics of the pressure pulse generated by a detonator underwater. An echinodome – an axisymmetric shell structure of optimum form – was subjected to a shock wave from the
K.M.M. El-Deeb, R. Royles
doaj   +1 more source

Fiber-Based SERS-Fluidic Polymeric Platforms for Improved Optical Analysis of Liquids

open access: yesBioengineering, 2023
Downsizing surface-enhanced Raman spectroscopy (SERS) within microfluidic devices has opened interesting perspectives for the development of low-cost and portable (bio)sensors for the optical analysis of liquid samples. Despite the research efforts, SERS-
Caterina Credi   +6 more
doaj   +1 more source

Colored visual stimuli evoke spectrally tuned neuronal responses across the central nervous system of zebrafish larvae

open access: yesBMC Biology, 2020
Background Visually guided behaviors such as optomotor and optokinetic responses, phototaxis, and prey capture are crucial for survival in zebrafish and become apparent after just a few days of development.
Chiara Fornetto   +3 more
doaj   +1 more source

FPGA implementation of adaptive sliding mode control and genetically optimized PID control for fractional-order induction motor system with uncertain load

open access: yesAdvances in Difference Equations, 2017
In this paper, we investigate the control of 4-D nonautonomous fractional-order uncertain model of a PI speed-regulated current-driven induction motor (FOIM) using a fractional-order adaptive sliding mode controller (FOASMC).
Karthikeyan Rajagopal   +3 more
doaj   +1 more source

Home - About - Disclaimer - Privacy