Results 71 to 80 of about 1,511,483 (263)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
An organ-on-chip device with integrated charge sensors and recording microelectrodes
Scientific Reports, 2023 Continuous monitoring of tissue microphysiology is a key enabling feature of the organ-on-chip (OoC) approach for in vitro drug screening and disease modeling.
Hande Aydogmus +6 more
doaj +1 more source
Gas recognition based on the physicochemical parameters determined by monitoring diffusion rates in microfluidic channels [PDF]
, 2014 This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014) +4 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Seeing the Unseen: Real-Time Micro-Expression Recognition with Action Units and GPT-Based Reasoning
Applied SciencesThis paper presents a real-time system for the detection and classification of facial micro-expressions, evaluated on the CASME II dataset. Micro-expressions are brief and subtle indicators of genuine emotions, posing significant challenges for automatic
Gabriela Laura Sălăgean +2 more
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Ain Shams Engineering JournalA deep deterministic policy gradient (DDPG)-based reinforcement learning (RL) controller is presented in this research to maximize the energy yield of the Archimedes Wave Swing (AWS) wave energy converter (WEC).
Ziad M. Ali +5 more
doaj +1 more source
Amenable groups and measure concentration on spheres
, 1998 It is proved that a discrete group $G$ is amenable if and only if for every unitary representation of $G$ in an infinite-dimensional Hilbert space $\cal H$ the maximal uniform compactification of the unit sphere $\s_{\cal H}$ has a $G$-fixed point, that ...
Pestov, Vladimir
core +1 more source