Results 41 to 50 of about 28,705 (244)
Drug Delivery, 2023 Nano- and micro-technologies can salvage drugs with very low solubility that were doomed to pre-clinical and clinical failure. A unique design approach to develop drug nanocrystals (NCs) loaded in extended release polymeric microparticles (MPs) for local
Carlos Rodríguez-Nogales +5 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Life Cycle Assessment of Apple Powders Produced by a Drum Drying Process
Chemical Engineering Transactions, 2015 This work aimed at evaluating the environmental performances of apple powders production based on a life cycle approach. Fruit powders are convenient, easy to handle and can be used to prepare several products such as snacks, beverages, bakery goods and ...
I. De Marco +3 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Global Challenges, 2023 Taking abundant and sustainable solar energy as the only energy source, solar‐powered interface evaporation has been regarded as a promising method to alleviate the pressure of freshwater shortage.
Dan Wei +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Yantu gongcheng xuebao, 2021 The leakage of canals in North Xinjiang is serious, and the behavior of expansive canal soil deteriorates rapidly, leading to frequent canal slides. In order to solve this problem, the canals are refilled and rebuilt, and a drainage system is set up at ...
DENG Ming-jiang 1, CAI Zheng-yin 2, 3, GUO Wan-li 3, HUANG Ying-hao 2, 3, ZHANG Chen 3
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
APPLICATION OF ELECTROPHYSICAL AND GAS-LIQUID TECHNOLOGIES FOR DRYING OF FRUIT RAW MATERIAL [PDF]
Техника и технология пищевых производств, 2015 The urgency of the problem of fruit raw materials drying under the controlled technological conditions consists in obtaining quality products with a high content of biologically active substances in these raw materials.
Myakinnikova E.I., Kasyanov G.I.
doaj
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source