Results 91 to 100 of about 602,701 (283)

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Epsilon-Guided Spatiotemporal Transformer: An Exponential Error Reduction for Multi-Memory Multilingual Sign Interpreter

IEEE Open Journal of the Computer Society
Sign language recognition faces critical challenges including temporal inconsistencies, inadequate cross-cultural feature representation, and limited real-time adaptability with poor generalization across diverse signing styles. We propose Spatiotemporal
Harapriya Kar, P Viswanathan
doaj   +1 more source

Generalized Orthogonality and Continued Fractions

Journal of Approximation Theory, 1995
The connection between continued fractions and orthogonality which is familiar for $J$-fractions and $T$-fractions is extended to what we call $R$-fractions of type I and II. These continued fractions are associated with recurrence relations that correspond to multipoint rational interpolants. A Favard type theorem is proved for each type.
Ismail, M.E.H., Masson, D.R.
openaire   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

General convergence of continued fractions [PDF]

Transactions of the American Mathematical Society, 1986
We introduce a new concept of convergence of continued fractions—general convergence. Moreover, we compare it to the ordinary convergence concept and to strong convergence. Finally, we prove some properties of general convergence.
openaire   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Generalizations of continuity

, 2018
Let X be a Hausdorff space in which each neighborhood an inexhaustible set (a set of Baire's second category), and let {N} denote the system of neighborhoods in X. Thus N (x) is a neighborhood of the element x. Let Y be a regular separable Hausdorff space and let {M} denote the system of neighborhoods in Y.
openaire   +3 more sources

Hyperelliptic continued fractions and generalized Jacobians [PDF]

American Journal of Mathematics, 2019
For a complex polynomial $D(t)$ of even degree, one may define the continued fraction of $\sqrt{D(t)}$. This was found relevant already by Abel in 1826, and later by Chebyshev, concerning integration of (hyperelliptic) differentials; they realized that, contrary to the classical case of square roots of positive integers treated by Lagrange and Galois ...
openaire   +3 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source