Results 101 to 110 of about 602,701 (283)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Mean value problems of Flett type for a Volterra operator

open access: yesElectronic Journal of Differential Equations, 2013
In this note we give a generalization of a mean value problem which can be viewed as a problem related to Volterra operators. This problem can be seen as a generalization of a result concerning the zeroes of a Volterra operator in the Banach space of ...
Cezar Lupu
doaj  

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

open access: yesFEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen   +6 more
wiley   +1 more source

Continuous Domain Generalization

open access: yes
23 pages, 9 figures.
Cai, Zekun   +6 more
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

On slightly I-continuous Multifunctions

open access: yesJournal of New Results in Science, 2016
The purpose of this paper is to introduce a new generalization of I-continuous multifunction called slightly Icontinuous multifunctions in topological ...
C Arivalazhai, N. Rajesh
doaj  

A generalization of strongly irreducible ideals with a view towards rings of continuous functions

open access: yesApplied General Topology
In this note, we introduce and study the concept of a semi-strongly irreducible ideal, a natural generalization of a strongly irreducible ideal. We say an ideal I of a commutative ring R is semi-strongly irreducible if for ideals J and K of R, the ...
Jamal Hashemi, Hossein Yari
doaj   +1 more source

Bleimann, Butzer, and Hahn Operators Based on the q-Integers

open access: yesJournal of Inequalities and Applications, 2008
We give a new generalization of Bleimann, Butzer, and Hahn operators, which includes q-integers. We investigate uniform approximation of these new operators on some subspace of bounded and continuous functions.
Ogün Doğru, Ali Aral
doaj   +1 more source

Hensel’s lemma for general continuous functions

open access: yesIndagationes Mathematicae, 2019
In the present paper, we generalize the well-known Hensel's lifting lemma to any continuous function $f : \mathbb{Z}_p\rightarrow \mathbb{Z}_p$. This answers a question posed by Axelsson and Khrennikov (2016) who showed the validity of Hensel's lemma for $1$- and for $p^ $-Lipschitz functions.
Kaneko, H., Stoll, T.
openaire   +4 more sources

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