Results 71 to 80 of about 602,701 (283)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Quantum interference of ultrastable twin optical beams

, 2004
We report the first measurement of the quantum phase-difference noise of an ultrastable nondegenerate optical parametric oscillator that emits twin beams classically phase-locked at exact frequency degeneracy.
A. Kuzmich, A. Luis, C. Fabre, C. Salomon, D. Lee, E. J. Mason, J. Mertz, M. Hillery, Olivier Pfister, P. Bouyer, R. Graham, S. Feng, S. Reynaud, Sheng Feng, T. Kim   +14 more
core   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Continuous speech recognition by convolutional neural networks

工程科学学报, 2015
Convolutional neural networks (CNNs), which show success in achieving translation invariance for many image processing tasks, were investigated for continuous speech recognition.
ZHANG Qing-qing, LIU Yong, PAN Jie-lin, YAN Yong-hong   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A note on bi-contractive projections on spaces of vector valued continuous functions

Concrete Operators, 2018
This paper concerns the analysis of the structure of bi-contractive projections on spaces of vector valued continuous functions and presents results that extend the characterization of bi-contractive projections given by the first author.
Botelho Fernanda, Rao T.S.S.R.K.
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Advancing Model Generalization in Continuous Cyclic Test-Time Adaptation with Matrix Perturbation Noise

Mathematics
Test-time adaptation (TTA) aims to optimize source-pretrained model parameters to target domains using only unlabeled test data. However, traditional TTA methods often risk overfitting to the specific, localized test domains, leading to compromised ...
Jinshen Jiang, Hao Yang, Lin Yang, Yun Zhou   +3 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source