Results 171 to 180 of about 5,191,391 (257)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Continuous improvement towards environmental protection for pharmaceuticals: advancing a strategy for Europe. [PDF]

Environ Sci Eur
Harrison S, Barnett C, Short S, Uluseker C, Silva PV, Pavlaki MD, Roberts S, Vieira M, Lofts S, Loureiro S, Spurgeon DJ.   +10 more
europepmc   +1 more source

Impact of practicing internal benchmarking on continuous improvement of cataract surgery outcomes: a retrospective observational study at Aravind Eye Hospitals, India. [PDF]

BMJ Open, 2023
Balu GS, Gupta S, Ravilla RD, Ravilla TD, Mertens H, Webers C, Vasudeva Rao S, van Merode F.   +7 more
europepmc   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Assessing impact on health, health care, and public support: The evolution of a CTSA hub's evaluation and continuous improvement program. [PDF]

J Clin Transl Sci
Welch LC, Daudelin D, Serrano L, Chen S, Cabrera A, Gibson E.   +5 more
europepmc   +1 more source

Commentary: Semper ad meliora: Continuous improvement in enhanced recovery pathways. [PDF]

JTCVS Open, 2022
Delman AM, Van Haren RM.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Implementing the Chinese mandatory antimicrobial stewardship program: barriers to continuous improvement. [PDF]

Health Policy Plan
Wang X, Lin L, Xu X, Harbarth S, Yakob L, Zhang R, Zhou X.   +6 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Continuous Improvement of Frontal Rhytids Following Glabella Only Treatments With Neuromodulators-A Clinical Prospective Pilot Study. [PDF]

J Cosmet Dermatol
Munoz-Lora VRM, Rogerio V, Thiesen V, Carnevali ACN, Bravo C, Shridharani SM, Eccleston D, Alfertshofer M, Germani M, Cotofana S.   +9 more
europepmc   +1 more source