Results 121 to 130 of about 3,548,705 (357)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children.

PLoS ONE, 2019
We investigated the hemodynamic and mortality effects of continuous ketamine infusion in critically ill pediatric patients. We conducted a retrospective cohort study in a tertiary pediatric intensive care unit (PICU).
Sojin Park, Ah Young Choi, Esther Park, Hyo Jung Park, Jaehyun Lee, Hukyoung Lee, JeongMee Kim, Joongbum Cho   +7 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Effect of acepromazine or dexmedetomidine associated with methadone on anesthetic induction with propofol at a rate of 1 mg/kg/min in healthy dogs: A randomized clinical trial

Open Veterinary Journal
Background: Presedation before general anesthesia helps reduce patient anxiety and facilitates anesthetic induction. Acepromazine and dexmedetomidine are widely used in dogs; however, these drugs cause cardiopulmonary alterations that may have a ...
Gabriela Pereira Souza, Lucas Wamser Fonseca Gonzaga, Pablo Henrique Silva Avelar, Jelieny Aparecida Claudino, Marilda Onghero Taffarel, Marcos Ferrante   +5 more
doaj   +1 more source

Effects of propofol in lipid-based emulsion and in microemulsion on the incidence of endothelial lesion in rabbits [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To compare the incidence of endothelial injury after single-dose or continuous propofol infusion in conventional lipid-based emulsion (LE) versus microemulsion (ME).
Cristian Durço Paço, Matheus Fachini Vane, Rafael Bicarato de Andrade, Maria Aparecida Domingues, Lidia Raquel de Carvalho, Daniela Carvalho dos Santos, Regina Kiomi Takahira, Norma Sueli Pinheiro Modolo, Luiz Antonio Vane   +8 more
doaj  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Characterization of differences in immune responses during bolus and continuous infusion endotoxin challenges using mathematical modelling

Experimental Physiology
Endotoxin administration is commonly used to study the inflammatory response, and though traditionally given as a bolus injection, it can be administered as a continuous infusion over multiple hours.
Kristen A. Windoloski, Susanne Janum, Ronan M. G. Berg, Mette S. Olufsen   +3 more
doaj   +1 more source

Continuous wound infusion as a valid alternative to tap block for postoperative analgesia after abdominal hysterectomy: A randomized controlled trial

Saudi Journal of Anaesthesia
Background: Total abdominal hysterectomy is a procedure associated with moderate to severe postoperative pain. Regional anesthesia techniques, such as fascial plane blocks, have shown promise in improving postoperative pain control.
Fabio Costa, Alessandro Ruggiero, Alessandro Strumia, Giuseppe Pascarella, Martina Cuccarelli, Francesco Plotti, Felice Eugenio Agrò, Massimiliano Carassiti, Rita Cataldo, Giovanni Ruggiero, Corrado Terranova, Carlo de Cicco Nardone, Roberto Montera, Roberto Angioli, Francesca Gargano, Eleonora Bruno, Davide Sammartini, Emanuele Sammartini, Arianna Martinelli, Lorenzo Schiavoni, Alessia Mattei   +20 more
doaj   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source