Results 121 to 130 of about 766,211 (305)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
On the Equivalence of Location Choice Models: Conditional Logit, Nested Logit and Poisson [PDF]
It is well understood that the two most popular empirical models of location choice - conditional logit and Poisson - return identical coefficient estimates when the regressors are not individual specific.
Kurt Schmidheiny, Marius Brülhart
core
On Continuous Connected Facility Location Problems [PDF]
, 2015 University of Minnesota Ph.D. dissertation. May 2015. Major: Industrial and Systems Engineering. Advisor: John Carlsson. 1 computer file (PDF);viii, 112 pages.An important but under-studied problem in location analysis is the so called connected facility
Jia, Fan
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
The Multi-Location Transshipment Problem with Positive Replenishment Lead Times
Transshipments, monitored movements of material at the same echelon of a supply chain, represent an effective pooling mechanism. With a single exception, research on transshipments overlooks replenishment lead times.
Gong, Y., Yucesan, E.
core
A Note on Bounds for the Estimation Error Variance of a Continuous Stream With Stationary Variogram
, 1998 In this paper, by the use of an Ostrowski type integral inequality for double integrals, we establish an upper bound for the estimation error variance of a continuous stream with stationary ...
Dragomir, Sever S, Barnett, Neil S
core
Continuous Location under Refraction
, 2014 In this paper we address the problem of locating a new facility on a $d$-dimensional space when the distance measure ($\ell_p$- or polyhedral-norms) is different at each one of the sides of a given hyperplane $\mathcal{H}$. We relate this problem with the physical phenomenon of refraction, and extends it to any finite dimension space and different ...
Blanco, Victor +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Towards Operational Systems for Continuous Navigation of Rescue Teams
, 2008 Self-protection is of rescue teams has absolute priority over all other objectives. Nevertheless rescue workers, such as fire fighters often face conditions that impose a combination of threats on them: severe physical and mental stress, limited or no ...
Mohammed Khider +5 more
core +1 more source