Results 61 to 70 of about 5,232,603 (249)

Self‐Driven Multistep Quantum Dot Synthesis Enabled by Autonomous Robotic Experimentation in Flow

Advanced Intelligent Systems, 2021
Identifying the optimal formulation of emerging inorganic lead halide perovskite quantum dots (LHP QDs) with their vast colloidal synthesis universe and multiple synthesis/postsynthesis processing parameters is a challenging undertaking for material‐ and
Kameel Abdel-Latif, Robert W. Epps, Fazel Bateni, Suyong Han, Kristofer G. Reyes, Milad Abolhasani   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Quasi‐Solid Composite Polymer Electrolyte‐Based Structural Batteries with High Ionic Conductivity and Excellent Mechanical Properties

Small Structures
Structural lithium batteries integrated with energy storage and mechanical load‐bearing capabilities hold great promise to revolutionize lightweight transport vehicles. However, the current development of structural batteries faces critical challenges in
Zeru Wang, Yue Hou, Sen Li, Zhuang Xu, Xiaotao Zhu, Bing Guo, Dong Lu, Ke Wang   +7 more
doaj   +1 more source

Continuous pharmaceutical manufacturing and its contemporary regulatory insights

Discover Applied Sciences
Nowadays, continuous manufacturing is a widely accepted production system in the pharmaceutical industry, as it provides several advantages over the conventional approach.
Atlaw Abate Alemie, E. A. Siraj, A. T. Yayehrad, Chernet Tafere, Tewodros Ayalew Tessema, A. Belete   +5 more
semanticscholar   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Enhancing Patient-Centric Drug Development: Coupling Hot Melt Extrusion with Fused Deposition Modeling and Pressure-Assisted Microsyringe Additive Manufacturing Platforms with Quality by Design

Pharmaceutics
In recent years, with the increasing patient population, the need for complex and patient-centric medications has increased enormously. Traditional manufacturing techniques such as direct blending, high shear granulation, and dry granulation can be used ...
Dinesh Nyavanandi, Preethi Mandati, Nithin Vidiyala, Prashanth Parupathi, Praveen Kolimi, Hemanth Kumar Mamidi   +5 more
doaj   +1 more source

Continuous manufacturing – the Green Chemistry promise?

Green Chemistry, 2019
We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes.
Luke Rogers, K. Jensen
semanticscholar   +1 more source

End-to-End Continuous Manufacturing of Conventional Compressed Tablets: from Flow Synthesis to Tableting through Integrated Crystallization and Filtration.

International journal of pharmaceutics, 2020
An end-to-end continuous pharmaceutical manufacturing process was developed for the production of conventional direct compressed tablets on a proof-of-concept level for the first time.
A. Domokos, Brigitta Nagy, Martin Gyürkés, A. Farkas, Kornélia Tacsi, H. Pataki, Y. Liu, A. Balogh, P. Firth, Botond Szilágyi, G. Marosi, Z. Nagy, Z. Nagy   +12 more
semanticscholar   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

Twin-screw granulation – a systematic analysis of process parameters

British Journal of Pharmacy, 2018
Twin-screw granulation has a significant advantage over traditional granulation methods leading to the possibility of continuous manufacturing. Although this technology has drawn attention in recent years, the general understanding of the process is ...
Margarethe Richter
doaj   +1 more source