Results 71 to 80 of about 2,098,564 (320)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Application of the Littlewood-Paley method to Calderon-Zygmund operators [PDF]

Surveys in Mathematics and its Applications, 2022
In this article, we establish the conditions for the pseudo-differential operator T under which this operator can be represented in convolution form with the singular kernel that satisfies |∂ xα ∂ zβ k(x,z)| ≤ Aβα(L)|z|-l-m-|β |-L for all z ≠ 0, and all ...
Mykola Yaremenko
doaj  

A commutator method for the diagonalization of Hankel operators

, 2010
We present a method for the explicit diagonalization of some Hankel operators. This method allows us to recover classical results on the diagonalization of Hankel operators with the absolutely continuous spectrum. It leads also to new results.
Yafaev, D. R.
core   +3 more sources

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

On a compound approximation operator of D.D. Stancu type

Journal of Numerical Analysis and Approximation Theory, 2006
In this note we consider a linear and positive compound approximation operator of D.D. Stancu type depending of several parameters; we give the expressions of this operator on the test functions, the conditions under which this operator converges to a ...
Maria Crăciun
doaj   +2 more sources

Efficient low-order refined preconditioners for high-order matrix-free continuous and discontinuous Galerkin methods [PDF]

SIAM Journal on Scientific Computing, 2019
In this paper, we design preconditioners for the matrix-free solution of high-order continuous and discontinuous Galerkin discretizations of elliptic problems based on FEM-SEM equivalence and additive Schwarz methods. The high-order operators are applied
Will Pazner
semanticscholar   +1 more source

The Newton Method for Operators with Hölder Continuous First Derivative

Journal of Optimization Theory and Applications, 2001
We analyze the convergence of the Newton method when the first Fréchet derivative of the operator involved is Hölder continuous. We calculate also the R-order of convergence and provide some a priori error bounds. Based on this study, we give some results on the existence and uniqueness of the solution for a nonlinear Hammerstein integral equation of ...
openaire   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

A Reflected–Forward–Backward Splitting Method for Monotone Inclusions Involving Lipschitz Operators in Banach Spaces

Mathematics
The reflected–forward–backward splitting (RFBS) method is well-established for solving monotone inclusion problems involving Lipschitz continuous operators in Hilbert spaces, where it converges weakly under mild assumptions.
Changchi Huang, Jigen Peng, Liqian Qin, Yuchao Tang   +3 more
doaj   +1 more source

Variational and operator methods for Maxwell-Stokes system

Discrete and Continuous Dynamical Systems. Series A, 2020
In this paper we revisit the nonlinear Maxwell system and Maxwell-Stokes system. One of the main feature of these systems is that existence of solutions depends not only on the natural of nonlinearity of the equations, but also on the type of the ...
Xingbin Pan
semanticscholar   +1 more source