Results 131 to 140 of about 583,715 (304)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

QIC Analysis: a practical tool to manage continuous quality improvement

open access: yes, 2007
Continuous quality improvement (CQI) has emerged as an imperative for businesses’ growth in today’s fiercely competitive environment. CQI is a never-ending process that seeks to achieve defect-free, high quality products or services. Different approaches
VANACORE, AMALIA
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

The Clinical Laboratory in the continuous improvement of quality

open access: yesRevista de Ciencias Médicas de Pinar del Río, 2019
El Laboratorio Clínico en la mejoría continua de la ...
Dianelys Díaz Padilla   +1 more
doaj  

Other title: Nursing Facility Preadmission Assessment and Referral Program educational bulletins.

open access: yes, 1994
Title from caption.; "Kansas Department of Social and Rehabilitation Services (SRS) and Bock Associates based on recommendations of the Nursing Facility Preadmission Assessment and Referral program Continuous Quality Improvement (CQI) team prepared the ...
Kansas. Department of Social and Rehabilitation Services.
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

Continuous quality improvement strategies in engineering curriculum

open access: yes, 2011
Engineering Education is facing new challenges to improve their outcomes toward higher quality to meet the job market demand and to keep abreast with current technologies.
Khalifa, Othman Omran, Ihsan, Sany Izan
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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