Results 91 to 100 of about 265,056 (306)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Incidence and drug treatment of emotional distress after cancer diagnosis : a matched primary care case-control study [PDF]

open access: yes, 2012
Notes This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.Peer ...
A J Lee   +33 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Making Transfusion Medicine a Journey from Good to Great by Using Quality Indicators and Bringing in Continuous Quality Improvement

open access: yesGlobal Journal of Transfusion Medicine, 2021
From its foundational years, transfusion medicine (TM) has been associated with errors and their reporting. Patient safety and quality were brought to the forefront of health care through the Institute of Medicine's two reports followed by the WHO (2004) forming a world alliance of 140 nations.
openaire   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Antibiotics: A food safety issue [PDF]

open access: yesWestern Balkan Journal of Agricultural Economics and Rural Development, 2020
Population growth and globalization are currently having many negative effects on the agri-food sector's ability to ensure safe and qualitative food. Use of medicines and chemicals in animal husbandry can considerably increases production and animals ...
Stancu Alina, Suvorov Nicolae
doaj  

Integrated electronic prescribing and robotic dispensing: a case study [PDF]

open access: yes, 2013
INTRODUCTION: To quantify the benefits of electronic prescribing directly linked to a robotic dispensing machine. CASE DESCRIPTION: Quantitative case study analysis is used on a single case.
C Whittlesea   +7 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

What causes non-adherence among some individuals on long term antiretroviral therapy? Experiences of individuals with poor viral suppression in Uganda

open access: yesAIDS Research and Therapy, 2019
Background Antiretroviral therapy (ART) use by people living with HIV reduces HIV transmission, morbidity, mortality, and improves quality of life. Good ART adherence is required to achieve these benefits.
Dominic Bukenya   +4 more
doaj   +1 more source

Brand and generic use of inhalation medication and frequency of switching in children and adults : a population-based cohort study [PDF]

open access: yes, 2018
BACKGROUND: The expiration of patents of brand inhalation medications and the ongoing pressure on healthcare budgets resulted in a growing market for generics.
de Jongste, Johan C   +8 more
core   +1 more source

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