Results 131 to 140 of about 14,224,726 (299)

A discrete-to-continuum model of protein complexes. [PDF]

Biomech Model Mechanobiol, 2022
Mariano PM, Bacci M.
europepmc   +1 more source

A semi-continuum model for fluid imbibition under nanoconfinement: Assessing fluid velocity jumps and meniscus acceleration

Fluid imbibition under nanoconfinement exhibits dynamics that significantly deviate from classical continuum predictions, posing unique challenges in understanding nanoscale transport phenomena.
Cencha, Luisa Guadalupe, Berli, Claudio Luis Alberto, Urteaga, Raul   +2 more
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

An orthotropic continuum model with substructure evolution for describing bone remodeling: an interpretation of the primary mechanism behind Wolff's law. [PDF]

Biomech Model Mechanobiol, 2023
Giorgio I, dell'Isola F, Andreaus U, Misra A.   +3 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The difference between semi-continuum model and Richards' equation for unsaturated porous media flow. [PDF]

Sci Rep, 2022
Vodák R, Fürst T, Šír M, Kmec J.
europepmc   +1 more source

An adaptive lumped-mass dynamic model and its control application for continuum robots [PDF]

Dynamic modeling for continuum robots remains challenging due to their large nonlinear deformation and the variation of dynamic parameters during movement.
Song, Zhibin, Zhang, Xu, Yang, Chenghao, Khanesar, Mojtaba A., Kang, Rongjie, Dai, Jian S., Branson, David T.   +6 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Stimulated Resonance Raman and Excited-State Dynamics in an Excitonically Coupled Bodipy Dimer: A Test for TD-DFT and the Polarizable Continuum Model. [PDF]

J Phys Chem A, 2023
Sandoval JS, Gong Q, Jiao L, McCamant DW.   +3 more
europepmc   +1 more source