Results 111 to 120 of about 14,224,726 (299)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Enhancing the precision of continuum robots in orthopedic surgery based on mechanical principles

Frontiers in Bioengineering and Biotechnology
IntroductionIn the field of orthopedic surgery, the notched continuum robot has garnered significant attention due to its passive compliance, making it particularly suitable for procedures in complex and delicate bone and joint regions.
Tongtao Pang, Tongtao Pang, Jinkui Liang, Zechen Lin, Xubin Zhang, Finxin Du, Finxin Du   +6 more
doaj   +1 more source

Continuum Models for Surface Growth [PDF]

, 2005
Lecture held at Oberwolfach Workshop "Multiscale modeling in epitaxial growth", submitted to Birkhauser Internatinal Series in Numerical Mathematics, 13 pages ...
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Stiffness evaluation of continuum robots based on the energy method and castigliano’s second theorem

Frontiers in Robotics and AI
IntroductionContinuum robots are studied and applied in neurosurgery due to their high flexibility and adaptability. The basic performance of continuum is mainly evaluated by stiffness, but there is no systematic and universal evaluation system.MethodsIn
Mengxue Yang, Zhicheng An, Zechen Lin, Yuhang Wang, Tongtao Pang, Tongtao Pang, Fuxin Du, Fuxin Du   +7 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Noncooperative Oligopoly in Markets with a Continuum of Traders [PDF]

In this paper, we study three prototypical models of noncooperative oligopoly in markets with a continuum of traders : the model of Cournot-Walras equilibrium of Codognato and Gabszewicz (1991), the model of Cournot-Nash equilibrium of Lloyd S.
Busetto, Francesca, Ghosal, Sayantan, Codognato, Giulio   +2 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Effect of Uncertainty in Water Vapor Continuum Absorption on CO2 Forcing, Longwave Feedback, and Climate Sensitivity

Journal of Advances in Modeling Earth Systems
We investigate the effect of uncertainty in water vapor continuum absorption at terrestrial wavenumbers on CO2 forcing F, longwave feedback λ, and climate sensitivity S at surface temperatures Ts between 270 and 330 K. We calculate this uncertainty using
Florian E. Roemer, Stefan A. Buehler, Lukas Kluft, Robert Pincus   +3 more
doaj   +1 more source