Results 81 to 90 of about 17,453 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Integral and Series Representations of Riemann's Zeta Function and Dirichlet's Eta Function and a Medley of Related Results

open access: yesJournal of Mathematics, 2013
Contour integral representations of Riemann's Zeta function and Dirichlet's Eta (alternating Zeta) function are presented and investigated. These representations flow naturally from methods developed in the 1800s, but somehow they do not appear in the ...
Michael S. Milgram
doaj   +1 more source

A Short Note on Integral Transformations and Conversion Formulas for Sequence Generating Functions

open access: yesAxioms, 2019
The purpose of this note is to provide an expository introduction to some more curious integral formulas and transformations involving generating functions.
Maxie D. Schmidt
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

A SUPER ZERO-REST-MASS-EQUATION [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 1990
Various authors have considered the Zero-rest-mass equation and the contour integral representation of its solutions. Ferber generalized these equations to supertwistor spaces with 2N odd components so that with N=O we get the standard ungraded twistors ...
doaj  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

NUMERICAL SOLUTION OF THE FLAT PROBLEM OF ELASTICITY THEORY WITH TAKING INTO ACCOUNT THE ANISOTROPY OF MATERIALS

open access: yesStructural Mechanics of Engineering Constructions and Buildings, 2012
Solving a problem of stress concentration around the contour of holes under different loads in anisotropic medium based on boundary integral approach is presented in this paper.
J N Nizomov, A A Hojiboe, O A Hojiboev
doaj  

New Bilateral Type Generating Function Associated with I-Function

open access: yesAbstract and Applied Analysis, 2014
We aim at establishing a new bilateral type generating function associated with the I-function and a Mellin-Barnes type of contour integral. The results derived here are of general character and can yield a number of (known and new) results in the theory
Praveen Agarwal   +2 more
doaj   +1 more source

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