Results 41 to 50 of about 38,455 (230)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Closure facilitates contour integration
Vision Research, 2007 Closed contours are often better perceived than those not fully enclosing an area, i.e., open contours. This facilitation of contour integration by closure, however, has been questioned arguing that in earlier studies closed contours were often "smoother" than open ones, because open contours usually had turning points.
Mathes, Birgit, Fahle, Manfred
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
The Development of Contour Processing: Evidence from Physiology and Psychophysics
Frontiers in Psychology, 2014 Object perception and pattern vision depend fundamentally upon the extraction of contours from the visual environment. In adulthood, contour or edge-level processing is supported by the Gestalt heuristics of proximity, collinearity and closure.
Gemma eTaylor +4 more
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The Analysis of Contour Integrals [PDF]
Abstract and Applied Analysis, 2008 For any n, the contour integral s2 = −λ, is associated with differential equation d2y(x)/dx2 + (λ + n(n + 1)/cosh2x)y(x) = 0. Explicit solutions for n = 1 are obtained. For n = 1, eigenvalues, eigenfunctions, spectral function, and eigenfunction expansions are explored.
Tanriverdi, Tanfer, Mcleod, JohnBryce
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FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Interaction of surface pattern and contour shape in the tilt after effects evoked by symmetry
Scientific Reports, 2021 Integration of multiple properties of an object is a fundamental function of the visual cortex in object recognition. For instance, surface patterns and contour shapes are thought to be crucial characteristics that jointly contribute to recognition ...
Ko Sakai, Yui Sakata, Ken Kurematsu
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Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
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Contour integration and aging: the effects of element spacing, collinearity and stimulus duration
Frontiers in Psychology, 2013 The ability to extract contours in cluttered visual scenes, which is a crucial step in visual processing, declines with healthy aging, but the reasons for this decline are not well understood. In three experiments, we examined how the effect of aging on
Eugenie eRoudaia +2 more
doaj +1 more source