Results 41 to 50 of about 37,534 (304)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Deep learning-assisted interactive contouring of lung cancer: Impact on contouring time and consistency. [PDF]

peer reviewed[en] BACKGROUND AND PURPOSE: To evaluate the impact of a deep learning (DL)-assisted interactive contouring tool on inter-observer variability and the time taken to complete tumour contouring.
Ellis, Shawn, Johnstone, Philippa, Burke, Emma, Trimpl, Michael J, Panakis, Niki, Campbell, Sorcha, Doyle, Emma, Bernard, Claire, Higgins, Geoffrey, Trimpl, Michael, Hustinx, Roland, Ajzensztejn, Daniel, Stride, Eleanor PJ, Gooding, Mark J, Vallis, Katherine A, Stride, Eleanor P J, Towers, Rebecca   +16 more
core   +1 more source

Performance of Commercial Deep Learning-Based Auto-Segmentation Software for Prostate Cancer Radiation Therapy Planning: A Systematic Review

Information
As yet, there is no systematic review focusing on benefits and issues of commercial deep learning-based auto-segmentation (DLAS) software for prostate cancer (PCa) radiation therapy (RT) planning despite that NRG Oncology has underscored such necessity ...
Curtise K. C. Ng
doaj   +1 more source

Real-world validation of Artificial Intelligence-based Computed Tomography auto-contouring for prostate cancer radiotherapy planning

Physics and Imaging in Radiation Oncology, 2023
Background and purpose: Artificial Intelligence (AI)-based auto-contouring for treatment planning in radiotherapy needs extensive clinical validation, including the impact of editing after automatic segmentation. The aims of this study were to assess the
Gabriele Palazzo, Paola Mangili, Chiara Deantoni, Andrei Fodor, Sara Broggi, Roberta Castriconi, Maria Giulia Ubeira Gabellini, Antonella del Vecchio, Nadia G. Di Muzio, Claudio Fiorino   +9 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Application of Non-Axisymmetric Endwall Contouring in a 1½ Stage, Rotating Turbine [PDF]

, 2011
Today gas turbines are a crucial part of the global power generation and aviation industries. Small improvements to the efficiencies of individual components within the gas flow path can, over time, lead to dramatic cost savings for the operator and at ...
SNEDDEN, GLEN,CAMPBELL, Snedden, Glen Campbell   +1 more
core  

Development of explanatory movies for the delineation of new organs at risk in neuro-oncology

Clinical and Translational Radiation Oncology, 2022
Ten new organs at risk (OARs) were recently introduced in the updated European Particle Therapy Network neurological contouring atlas. Despite the use of the illustrated atlas and descriptive text, interindividual contouring variations may persist.
Dario Di Perri, David Hofstede, Alida Postma, Catharina M.L. Zegers, Lieke In't Ven, Frank Hoebers, Wouter van Elmpt, Lindsey Verheesen, Hilde Beurskens, Esther G.C. Troost, Inge Compter, Danielle B.P. Eekers   +11 more
doaj   +1 more source

Contour Grouping Based on Contour-Skeleton Duality [PDF]

International Journal of Computer Vision, 2009
In this paper we present a method for grouping relevant object contours in edge maps by taking advantage of contour-skeleton duality. Regularizing contours and skeletons simultaneously allows us to combine both low level perceptual constraints as well as higher level model constraints in a very effective way.
Nagesh Adluru, Longin Jan Latecki
openaire   +2 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source